Conserved Protein Domain Family
BTB_POZ_M2BP

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cd18304: BTB_POZ_M2BP 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP)
M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.
Statistics
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PSSM-Id: 349613
Aligned: 5 rows
Threshold Bit Score: 159.185
Created: 4-Dec-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q08380       136 SRELSEALGQIFDSQrGCDLSISVNvqg--edALGFCGHTVILTAnLEAQALWKepgSNVTMSVDaeCVPMVRDLLRYFY 213 human
Q6NY73       147 SLGLSDDLGLLFDSEdGCDFTIAVRdls-eeaELTFCVHRVILMIyPELNLTHDt--RNITVDISqtCHTHVPRFLRYLY 223 zebrafish
XP_020669604 156 SGSFSEDLSKLYDSQqDCDLNIIVLvaennteYKRLCAHRLILRAsSEASFLLQkgnDSWILQVEeeCLPNVNNFLRYFY 235 central bearded...
XP_014340043 144 SMDFAESLKNLYETRqFCDFNISVKtngkeseTSIICTHRIILLLnVDANFMVKdgaENFTLTVDeeCTPYVDDFIRYLY 223 coelacanth
XP_007884077 152 PMELQQSLSLLYLSQkHCQVKILVLtaqggpvRLHLCAHRLILALsQDGNSLSHnrsSGIQLVVPsdCLAFVEDFIRYFY 231 elephant shark
Q08380       214 SRRIDItlSSVKCFHKLASAYGARQLQGYCASLF 247 human
Q6NY73       224 TRQIDVstTSAQCLHQLAFIFGVQKLMEDVGRVF 257 zebrafish
XP_020669604 236 TRQLNItvDSVKCFHKLASVYHVPRLRAYCTQVF 269 central bearded dragon
XP_014340043 224 IKKISVtlKSSKCIHKLASMYGILELQEFCSQLF 257 coelacanth
XP_007884077 232 TKSMDItlASVRCVHELASSYGVRALREACHQLL 265 elephant shark
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