4HXI


Conserved Protein Domain Family
BTB_POZ_KLHL2-like
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cd18235: BTB_POZ_KLHL2-like 
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BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3
The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.
Links
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Statistics
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PSSM-Id: 349544
Aligned: 11 rows
Threshold Bit Score: 229.237
Created: 13-Sep-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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cullin binding
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:cullin binding site [polypeptide binding site]
Evidence:
  • Structure:4HXI: Homo sapiens KLHL3 in complex with Cullin-3, contacts at 3A.
  • Comment:KLHL3/KLHL2 interacts with Cullin-3 to form a CUL3-KLHL E3 ubiquitin ligase complex.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      ##  ##   ## #      ####            
4HXI_A         30 NPAHMGKAFKVMNELRSKQlLCDVMIVAE-DVEIEAHRVVLAACSPYFCAMFTGDMsESAAAAIEIKDVDGQTLSKLIDY 108  human
O95198         35 NPWHMKKAFKVMNELRSQNlLCDVTIVAE-DMEISAHRVVLAACSPYFHAMFTGEMsESRAKRVRIKEVDGWTLRMLIDY 113  human
XP_011677556   24 NNLHTQKAFEVLNVFRKQNiLCDVILEAE-GVEIPAHRIVLASCSQYFSAMFTSELsESRAEKIILQEVDGRALSLLIDF 102  purple sea ur...
XP_013388754   23 HPHHTQKAFDVLNMMRKQAlLCDVLIIVD-GKEIPAHKSVLSSCSPYFYAMFTNDLsEARSNRVMLQDVDGKALTQLIDF 101  Lingula anatina
XP_002730487   45 NLQHTNKAFDILNIFRKQNqLCDVILEAE-GVEIPAHRVVLASCSPYFSAMFTGELaESRAERVTLQEIDGKALNLLVDY 123  Saccoglossus ...
XP_002596248    9 NHSHTQKAFEVMNHLRRQSqLCDVILEAD-GVEVPAHRLVLASCSSYFHAMFTGELsEAHAERVTMQEVDGKALVLLVDY 87   Florida lancelet
EFX87725       39 NSDHFSKSFAKFNMMRKEKfLCDVVLITTnQEEFPAHRAILASCSPYFHAMFSCFE-ESNQNRIVLQDVDPKALGLLLEY 117  common water ...
ELU16789       18 NQGHTQKAFEVLNVLRGNQlLCDVALSAD-GVELWAHRVVLAACSPYFYAMFTADLaEAHTERIVLQEIDNRALTLLIDF 96   Capitella teleta
XP_009862126   42 NDVHTKDAFASMNALRKSNvLCDVILVAG-DLEIPVHRLVMASGSPYFMAMFNGMMsESSANRVKLNGIDGKALLQLVDY 120  vase tunicate
Q04652        136 NEQHTARSFDAMNEMRKQKqLCDVILVAD-DVEIHAHRMVLASCSPYFYAMFTSFE-ESRQARITLQSVDARALELLIDY 213  fruit fly
E7F6F9         42 THMRKAFLLMNDLRSHSRKmLCDVLLVAG-EVEIPAHRVVLASCSPYFCAMFTGDMsESKANHVEIRDVDGQTLLKLVDY 120  zebrafish

Feature 1                          #  ## #    #             
4HXI_A        109 IYTAEIEVTEENVQVLLPAASLLQLmDVRQNCCDFLQSQLHP 150  human
O95198        114 VYTAEIQVTEENVQVLLPAAGLLQLqDVKKTCCEFLESQLHP 155  human
XP_011677556  103 VYTSEVQVTEENVQTLLPAASLLQLnDVRDACCDFLQKQLHP 144  purple sea urchin
XP_013388754  102 IYTSEIGVTEENVQILLSAANLLQLvEVRNACCEFLQSQLHP 143  Lingula anatina
XP_002730487  124 VYSAEVQVTEDNVQALLPAANLLQLpDVRDACCDFLQRQLHP 165  Saccoglossus kowalevskii
XP_002596248   88 VYSSVIQVTEENVQALLPAANLLQLtDVRDACCDFLQSQLHP 129  Florida lancelet
EFX87725      118 VYSSEIQVNEDNVQILLPAANLLQMfEVKEFCSEFLVTQLHP 159  common water flea
ELU16789       97 MYTAEIQVTEDNVQSLLPAANILQLvEVRDAACEFLQSQLHP 138  Capitella teleta
XP_009862126  121 VYTAQIQVTEENVQSLLPAASLLELtFVRESCCCFLQSQLHP 162  vase tunicate
Q04652        214 VYTATVEVNEDNVQVLLTAANLLQLtDVRDACCDFLQTQLDA 255  fruit fly
E7F6F9        121 IYSAEIEVSEENVQVLLPAASLLQLmDVRQVCCDFLQTQLHP 162  zebrafish

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