Conserved Protein Domain Family
SpoU-like_MRM1

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cd18105: SpoU-like_MRM1 
SAM-dependent rRNA methylase related to MRM1
MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Statistics
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PSSM-Id: 349978
Aligned: 55 rows
Threshold Bit Score: 163.073
Created: 14-Jan-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative SAMputative dimer
Feature 1:putative SAM binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other SPOUT methylases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_079140    146 LWLVLDGIQDPRNFGAVLRSAHFLGvDKVITSRrns--cpLTPVVSKSSAGAMEVMDVFSTddLTGFLQTKAqqGWLVAG 223 human
CCF59239     174 LGVLMDKITDPFNVGSIVRSCFYMGvDFALSAGsvnvekgFSSTIHKASSGAIESIPVYNIddKVKFITAMKdkGWVFVA 253 Kazachstania af...
EGR33282     133 IIVFLDQITDPQNFGAILRTCFYLGvDNVVVEEskr--cpLNSTVSKTSSGAMELMDIFCTsnSVEFIKECQklKWKVFA 210 Ichthyophthiriu...
CCD78155     144 TVLLLDHMMDTMNFGNILRSAAFFGiSAVILSTspc--vsPSPLISKISVGAMESILFYRLtdTVMDMKSLSnaGFLIVG 221 Schistosoma man...
KHN73675     172 IFLYLDRVLDPGNIGAIVRSCFYFDiDGVIMARdlg-pktPTPAMSKASAGALERFPIYNIeeFASFHERMRniGFKFIG 250 dog roundworm
XP_001440955 106 NFVLLDSVQDPQNFGAILRVCFFLGiNTVIVEKkgq--cpLSPTVSKTSAGALELMNIFETdnLANFVKQRKh-EFQVIG 182 Paramecium tetr...
ELU02573     148 LWVILDRIQDPMNFGAVLRSCYYLGvHRVITSSkeg--caLSPVVCKASAGALELAPLFKTsnLTDFIQAWRekGFRILG 225 Capitella teleta
NP_499333    132 VSIFVDKVLDPGNLGAIGRSAWYFGaDGLGLVKgrg-pksITPAMIKSSCGALEHLPVQQFlnFNEFRDKIKaaGGELVA 210 nematode
EYB87224     151 TTVYLDNVLDPGNFGAIARSALFFGcEQIAYAEgrg-psrITPAMSKASCGALECSRVVRVpsFLSFHKTLKsaGAVFVG 229 Ancylostoma cey...
EGD78939     196 LYVLVTGVQDPVNLGSILRSSYCLGvRRVFLSDrqt--lkPTSTVSKSSAGALELLDVHTVrdEASFIAHAAdhGFLSFA 273 Salpingoeca ros...
Feature 1        # #                                                   ####  #             ## #  
NP_079140    224 TVGCpstedpq--------------------sseipiMSCLEFlw--erPTLLVLGNEGsGLSQEVQAscqlLLTILPRr 281 human
CCF59239     254 ATVDsdnse------------------------krilMDDLRIvgg-tsGVILVLGSEGqGISKRVQHecdyTVEIPVRa 308 Kazachstania af...
EGR33282     211 CGVNfg-----------------------------qnNKQISLdkl-klNIVIILGSEGsGVNKELSNqadkILYINQSi 260 Ichthyophthiriu...
CCD78155     222 TCGEsqlpsskvskstd--------llkpdevganndNTGVYPr-----PLILALGSESrGLSENVLNscdlLLRIPGYg 288 Schistosoma man...
KHN73675     251 TADEnsava-----------------------kgyqsPIRLCDfrqtkdKTVVILGDEGrGVSSEILDqcdyIVQIPSPk 307 dog roundworm
XP_001440955 183 SGFEsns----------------------------ipIDEFQKdqn-kpKKIIIFGSESsGIRTELFKqcdtIVNIMTSr 233 Paramecium tetr...
ELU02573     226 TGMPtegea------------------------csspVIPLNTidm-qqDTILIFGNEGkGMDTELISlcdaLLTISPRk 280 Capitella teleta
NP_499333    211 TCDPgaaek------------------------agisAKSLDQwtp-ekPVGIVLGDEGvGISRGILNlcdtVISISPVr 265 nematode
EYB87224     230 TSDAvsarkf---------------------gkptieLNELEVqs--gqKLVVVLGDEGlGVSDEVMNncdiLLSISSSc 286 Ancylostoma cey...
EGD78939     274 ACMQpnansqqphmstadlllptqastppslssslpsADALASgat-arGALLVVGNEHrGIHANVVDactaTLAVDQHr 352 Salpingoeca ros...
Feature 1                       ## #  #        
NP_079140    282 qlp--------pglESLNVSVAAGILLHSI 303 human
CCF59239     309 rkk-------nrsvDSLNVGVAAGILLEKL 331 Kazachstania africana CBS 2517
EGR33282     261 yfekpi-vfpntlvDSLNVNSAASIIIENI 289 Ichthyophthirius multifiliis
CCD78155     289 dstklnqcisqtipSSLNVSVAAGILLYQL 318 Schistosoma mansoni
KHN73675     308 keya------ecsvKSLNVSVSAAILLYYL 331 dog roundworm
XP_001440955 234 htfp------etlvDSLNVSVSAGIILQSV 257 Paramecium tetraurelia strain d4-2
ELU02573     281 alh--------qslDSLNVSVAAGIVLHHL 302 Capitella teleta
NP_499333    266 kdg--------snvTSLNVSVVAGILLHHI 287 nematode
EYB87224     287 akq--------tsvNSLNVSVVAGILLHHI 308 Ancylostoma ceylanicum
EGD78939     353 sh----------lvDSLNVGVAAGILIHAI 372 Salpingoeca rosetta

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