1GZ0,1GZ0


Conserved Protein Domain Family
SpoU-like_RlmB
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cd18103: SpoU-like_RlmB 
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SAM-dependent rRNA methylase related to RlmB
23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349976
Aligned: 188 rows
Threshold Bit Score: 128.271
Created: 12-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative SAMhomodimer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative SAM binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other SPOUT methylases
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   # 
1GZ0_D    106 FLLILDGVTDPHNLGACLRSADAAGvHAVIVPKdrsaqlnATAKKVACGAAESVPLIRVtNLARTXRXLQeeNIWIVGTA 185 Escherichia coli
CDD02129  105 YFVLLDGIEDPFNFGYVLRTLYTAGvDGVFLPErnflsaaSTVIRSSAGTSELLNIASYnDVDELFAFLKenGIFIVATA 184 Ruminococcus sp. C...
EFC05759   87 FLLVLEGVVDPFNFGYMVRTAYSAGvDGILIPEyhwhdleSVILKSSAGAFDHCSIIPSkDLAQDLRLLKekGFTIYAGY 166 Bulleidia extructa...
EFW24064   90 FLVLLEGVEDPFNLGYIIRTLYSAGcDGLILPRhdwasaeSTIAKSSAGAFEYMNIVMSdDLPKLVKDIKkqGIKTYAAM 169 Solobacterium moor...
EEC90001   90 FLCYIDGVEDPYNLGSISRTLYASGcDAMILPKrdwsfaeQTILKASAGAYEKLPIYFVdADEELVNYCKknNLPILCAH 169 Holdemanella bifor...
CDC63701  113 FYVFLDGIEDPYNFGYVLRSLYAAGvDGVVLSErnwmsaaGTVARASAGTSELLSVCIA-DPASVPGVFRqcGYKILAAG 191 Clostridium sp. CA...
EEF67238   91 FIAVLEGIEDPFNLGYAFRTLYAAGcTGVLMGSrdwqtaqPTIVKSSAGASEQLAWCLCeDLGAAVRQCRqaGCVLYCAQ 170 Holdemania filifor...
EOS60889   91 TIFYVEGLEDPYNLGSICRTIYAAGaTLLILPTrdwsnasDTILKASAGAFEKLDIAYA-SEEQCIQYLQkhHIPLICAY 169 Firmicutes bacteri...
CCZ20571  110 FYVMLEGIEDPYNFGYCLRSLYAAGvTGIILENhnwtgvsGIVARASAGASEMFDMRVSeDFAETAKAFRaaGYKFAVAD 189 Ruminococcus sp. C...
EDP10883   93 FLALVEGVEDPFNFGYVLRTLYAAGcDGIIVGKrnwtsavNTVTRASAGASEYINIFVSeDMEATIQQMKkqQITFLCAQ 172 [Eubacterium] doli...

Feature 1     #                   ####  #             ## #      ## #  #        
1GZ0_D    186 GEa-DHTLYQSKxtgRLALVXGAEGEGXRRLTREhCDELISIPXAg-sVSSLNVSVATGICLFEA 248 Escherichia coli
CDD02129  185 KTneSTDIFAASfkrPLCVVIGGEKRGINKTVSKyADKTVSIVYPrdtGISLSASSAAAIIAYQV 249 Ruminococcus sp. CAG:382
EFC05759  167 RDn-AIVYDEADytnPTVFCVGGELRGLSKQVLEqVDQAVYIPYAngfKNALNAASACSVFCFEV 230 Bulleidia extructa W1219
EFW24064  170 RKd-AITYLEADyrqPCLLAIGGEMRGLSSAVRNeIERNIYIPYAndfRNALNAASAAAVLSFEV 233 Solobacterium moorei F0204
EEC90001  170 RKd-AVGLYDYTfesDFCLCLGGALRGLSSTITAaSKQNIVVEYGrdfRNALDSASAAAVFSFEI 233 Holdemanella biformis DSM 3989
CDC63701  192 IRn-SVSLYDADmhfPLLMIVGGEKRGISAKLLSqADEIVRIDYGrvfRGSLSAASAATVLAFEA 255 Clostridium sp. CAG:448
EEF67238  171 RSd-AIDYFDADfnqPIVLAIGGELRGLSRDVLEqSDQNIVIPYArpvRSALNGTSAVAAISFEV 234 Holdemania filiformis DSM 12042
EOS60889  170 RKd-ALPLSTFRypkTCCIAVGGAMRGLSKKILShSDYNVYIQYGreyRNALDTASSTAIFAFDK 233 Firmicutes bacterium M10-2
CCZ20571  190 KSekSRSIYDCAlkfPLLLAVGGERRGNTKAALEvADEIIELDYGrdfPAALSAASAASVIAFEI 254 Ruminococcus sp. CAG:724
EDP10883  173 RKd-AISLYDYHfpkKCCIAIGGEMRGLSKAVMAqSDQNLFIPYRsefRNAMTAAASTAIFAFEL 236 [Eubacterium] dolichum DSM 3991

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