Conserved Protein Domain Family
DEXHc_DHX35
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cd17980: DEXHc_DHX35 
DEXH-box helicase domain of DEAH-box helicase 35
DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350738
Aligned: 7 rows
Threshold Bit Score: 308.244
Created: 18-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human RNA helicase A (DHX9) with bound Mn.ADP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #                        #######                                 #              
Q9H5Z1        54 LPVFKLRNHILYLIEnYQTVVIVGETGCGKSTQIPQYLAEAGwtaegrVVGVTQPRRVAAVTVAGRVAEErgav-lghEV 132 human
XP_004947059  54 LPVFKLRNHILYLVEsYQTLVIVGETGCGKSTQIPQYLAEAGwtaegrVVGVTQPRRVAAVSVAGRVADErgav-lghEV 132 chicken
Q9BKQ8        77 LPIFKNRGHILYMCErYRTIIIVGETGCGKSTQVPQFLLEAGwaadgrQIVITQPRRVAVVTLATRVAEEkdci-lghDV 155 Caenorhabditis ...
CBJ30697      43 LPIYRHRNSVLFAVQkHRAIVLVGETGCGKTTQIPQYLHEAGwtagnrAVVCTQPRRVAAFTVATRVAEEmgsr-lgeTV 121 Ectocarpus sili...
NP_001072515  52 LPVFKLRNHILYLVEnYQTVVIIGETGCGKSTQIPQYLTEAGwtaegrVVGVTQPRRVAAVSVAGRVAEErgav-lghEV 130 tropical clawed...
XP_645858     55 LPIYQNRKHILYLLEkYSTLVIIGNTGCGKSTQIPQYLFESGwsdgfrTILCTQPRRVAAISLAERVAQEmgeqhvgkTV 134 Dictyostelium d...
NP_567558     48 LPVYKYRTEILYLVEnHATTIIVGETGSGKTTQIPQYLKEAGwaeggrVIACTQPRRLAVQAVSARVAEEmgvn-lgeEV 126 thale cress

Feature 1                                                   ##                                   
Q9H5Z1       133 GYCIRFDDCTDqlatRIKFLTDGMLVREMmvdplltkySVIMLDEAHERTlytDIAIGLLKKIQKkr----------gdL 202 human
XP_004947059 133 GYCIRFDDCTDpqatRIKFLTDGMLVREMmadplltrySVLMLDEAHERTlytDIAIGLLKKIQKkr----------gdL 202 chicken
Q9BKQ8       156 GYTVRFDDVSDkd-tKVKFMTDGLLLREIladpllskySIIMIDEAHERScntDILLGLLRKIIQir----------ndL 224 Caenorhabditis ...
CBJ30697     122 GYSVRFDSRVGpa-tKVKFCTDGMLLREMmldplltaySVVMLDEAHERTiynDILFGLLKKIMRkr----------keL 190 Ectocarpus sili...
NP_001072515 131 GYCIRFDDCTDpqatRIKFLTDGMLVREMmsdplltrySVLMLDEAHERTlytDIAIGLLKKVQKkr----------gdL 200 tropical clawed...
XP_645858    135 GYSVRFDEKISdietRIKYVTDGMLIREMmldplllkySVIMIDEAHERSlqtDLLMGLLKKVQKkrnstnnnnnndnsL 214 Dictyostelium d...
NP_567558    127 GYTIRFEDHTTsgvtSVKFLTDGVLIREMmedplltkySVIMIDEAHERSistDILLGLLKKIQRrr----------peL 196 thale cress

Feature 1                                                   
Q9H5Z1       203 RLIVASATldADKFRDFFnqnetsd-------pardtcVILTV 238 human
XP_004947059 203 RLIVASATldAEKFRDFFnqndtgd-------pskdtsVILTV 238 chicken
Q9BKQ8       225 RIIVSSATldAELFKDFFemnetgn-------sdkdtaGIISV 260 Caenorhabditis elegans
CBJ30697     191 RVIVASATldAEQFRDFFetntnnn-------anantaTILSI 226 Ectocarpus siliculosus
NP_001072515 201 RLVVASATldAEKFKAFFnqndtnd-------psrdtcAILTV 236 tropical clawed frog
XP_645858    215 KLIISSATlnANDFFNFFnynqtnd-------kskdtsTILSI 250 Dictyostelium discoideum AX4
NP_567558    197 RLIISSATieAKTMSNFFnsskkrhapegstpgpklepAILSV 239 thale cress

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