2WJV,4B3G,5EAN,5MZN,6XEZ,2XZL


Conserved Protein Domain Family
DEXXQc_Upf1-like
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cd17934: DEXXQc_Upf1-like 
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DEXXQ-box helicase domain of Upf1-like helicase
The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 438708
Aligned: 55 rows
Threshold Bit Score: 71.4973
Created: 21-Jul-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2XZL; Saccharomyces cerevisiae Upf1 with bound ATP, contacts at 4A
  • Structure:6XEZ: SARS-CoV-2 Nsp13 binds ADP; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ######                                                                  
2WJV_A        373 LSLIQGPPGTGKTVTSATIVYhlarq-----------------gngpVLVCAPSNiAVDQLtekihqtglkvvrlcaksr 435  human
2XZL_A        377 LSLIQGPPGTGKTVTSATIVYhlski-----------------hkdrILVCAPSNvAVDHLaaklrdlglkvvrltaksr 439  baker's yeast
XP_648902     501 LTLVHGVFGSGKSHLLSVLCIllas------------------lnykVLVCASTNvAVDRVleslltknyksffrvgslk 562  Entamoeba his...
XP_001318327  585 ILLVHGIFGAGKSHLLSVIVTfldkvlt------------manrddkILIAATTNvAVDNVllnllddgfdnltrvgsvk 652  Trichomonas v...
ABO95512       88 VRLIHGPFGSGKTHTIAAFVTkaaell--------------kssngrIMIAAHTNvAVDRVlqslleagftdfirvgsvr 153  Ostreococcus ...
NP_001032412 2169 FTVIQGPPGTGKTIVGLHIVFwfhksnqeqvqpggpprgekrlggpcILYCGPSNkSVDVLaglllrrmelkplrvyseq 2248 human
CAQ34975      272 FAFLEGPPGSGKTTAICELILqlik------------------rgkrILLCASTHvAVDNVlermmseeniyrdmvlpvr 333  causative age...
XP_001837738  388 SIIVHGPPGTGKTTTIAAISRiwdm------------------hdcpVWIVAHSNvAVKNIanalfkrdvdfkiivskef 449  Coprinopsis c...
EFN58598      853 VCLVHGPFGSGKSTLLVALLHfllqqhgra---------gsplagarVLVSAHTNvAVDRVlvgllesgcsdflrvgplr 923  Chlorella var...
CBZ53871     1150 IVLVQGPPGTGKTLVAACILSlwaagld-------------getaspIFAGAGTHaAVDALrsklgnlgvrshtvgmler 1216 Neospora cani...

Feature 1                                                                                         
2WJV_A        436 eaidspvsflalhnqirnmdsmpelqklqql-------------------------kdetgelssadekryralkrtaer 490  human
2XZL_A        440 edvessvsnlalhnlvgrgakgelknllkl---------------------------kdevgelsasdtkrfvklvrkte 492  baker's yeast
XP_648902     563 kiskqilpftlsendglndlrelkkekllt----------------------------neerriieneinerksgsiekr 614  Entamoeba his...
XP_001318327  653 nmsrkvlpyatgnsdldelktlqsmem----------------------------------nkevelaiknaqeekrtkt 698  Trichomonas v...
ABO95512      154 kidpvilpyslhvktgkgpsqakeleamlket-----------------------tsvrkrailqkeietlssgkvgmrk 210  Ostreococcus ...
NP_001032412 2249 aeasefpvprvgsrkllrkspregrpnqslrsitlhhrirqapnpysseikafdtrlqrgelfsredlvwykkvlweark 2328 human
CAQ34975      334 igdkssvsqkakpwqleefvktertrllkhlqqqp-----------------hisvsqkllkskvgegkhiverlvleaa 396  causative age...
XP_001837738  450 yeewhehlylaieaklirtdel--------------------------------------------ptdpvglervigds 485  Coprinopsis c...
EFN58598      924 rvsrrllaqslhasesrasagaaaelremlkea----------------------gspaeaaairaelaaaekgadrqrk 981  Chlorella var...
CBZ53871     1217 rgdyspavggysprrs-------------------------------------------------------stasgtqgq 1241 Neospora cani...

Feature 1                                                                        #                
2WJV_A        491 ellmnadvicctcvgagdprlakmqfRSILIDESTQatepecm---vpvvlgaKQLILVGDHCQLGpvvmckkaakagls 567  human
2XZL_A        493 aeilnkadvvcctcvgagdkrldtkfRTVLIDESTQasepecl---ipivkgaKQVILVGDHQQLGpvilerkaadaglk 569  baker's yeast
XP_648902     615 shdiktasivgvtcasstnpllnhsyDIILLDEATQtiepmlli--pilrfnpKCIVCVGDPMQLDpvlqtdhlsat--- 689  Entamoeba his...
XP_001318327  699 skidicrvtgvtcaacqfeciqnkkfTFVLLDECSQqpepisf---lpisfgcQQLICCGDPMQLPptisshsplglg-- 773  Trichomonas v...
ABO95512      211 allkkcsvvgvtcyssshedlknmefSVVVLDECSQmtepssll--pvvqsrcKTLVAVGDPLQLSpvvadvpesnrska 288  Ostreococcus ...
NP_001032412 2329 feldrhevilctcscaasaslkildvRQILVDEAGMatepetli-plvqfpqaEKVVLLGDHKQLRpvvknerlqnlg-- 2405 human
CAQ34975      397 nlvcgttigllqhpdiknkqstspifDVMIIDEASKttfqefl----vpavlaKRWIMVGDPKQLSpyvddeatevnlqp 472  causative age...
XP_001837738  486 cvilstlstlsnpaldqnkmfelvpvERLIVDEASQirvfeflhlfekfqkdlEKVYFFGDPCQLSpfnhekvrtmkt-- 563  Coprinopsis c...
EFN58598      982 rllktvpvvgvtccsamlaaldgqrfDVLLLDESSQmveplsai--pllraqaRFLIAAGDPLQLPpviaspvhvtqapp 1059 Chlorella var...
CBZ53871     1242 tlayrqrvpvfvdtvyqgqnlrriapRRILIDEASQitefrsli--vlaqtkcTKLVLVGDPAQISgqsvqacpvmvrs- 1318 Neospora cani...

Feature 1                                                ##
2WJV_A        568 -------------------qslferlvvlgirPIRLQVQYR 589  human
2XZL_A        570 -------------------qslferlislghvPIRLEVQYR 591  baker's yeast
XP_648902     690 ----------------------lfqrlcsleiPIMLKVQYR 708  Entamoeba histolytica HM-1:IMSS
XP_001318327  774 --------------------rplfsrlirvypPVMLSIQYR 794  Trichomonas vaginalis G3
ABO95512      289 nvtr-----------nplkrtlfsrlsdaghsKVTLRTQYR 318  Ostreococcus lucimarinus CCE9901
NP_001032412 2406 --------------------ldrslferyhedAHMLDTQYR 2426 human
CAQ34975      473 c----------------lqdsyqreacadifsARQINIQKR 497  causative agent of fish pasteurellosis
XP_001837738  564 --------------------vfdlahlntnerRWMLKTQYR 584  Coprinopsis cinerea okayama7#130
EFN58598     1060 hrpqqaqqqqereqpqgllrplfvrlsalglpLFLLRRQYR 1100 Chlorella variabilis
CBZ53871     1319 -------------------afdsfltqsavphYFLLDTQFR 1340 Neospora caninum Liverpool

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