3LLM,5D0U,5LQW,5MQF,5LJ5,2V6I


Conserved Protein Domain Family
DEXHc_RHA-like
?
cd17917: DEXHc_RHA-like 
Click on image for an interactive view with Cn3D
DEXH-box helicase domain of DEAD-like helicase RHA family proteins
The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
?
Statistics
?
PSSM-Id: 438707
Aligned: 104 rows
Threshold Bit Score: 100.227
Created: 16-May-2011
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ATP bindingDEAD box
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3LLM; Homo sapiens DHX9 with bound Mn.ADP, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #######                                                    #           
3LLM_A         76 NSVVIIRGATGCGKTTQVPQFILDDFiqndr----------------aaecNIVVTQPRRISAVSVAERVAFErgee-pg 138  human
XP_011523555   69 NSFLIVTGNTGSGKTTQLPKYLYEAGfsq--------------------hgMIGVTQPRKVAAISVAQRVAEEmkct-lg 127  human
NP_415931      93 HQVVIVAGETGSGKTTQLPKICMELGrgi--------------------kgLIGHTQPRRLAARTVANRIAEElkte-pg 151  Enterobacteri...
XP_001349312   20 NNLIIIKGETGCGKTTQVPQIINEIFfdkkekkydnikhkndekkkrkekkKMLISLPRRVATITVAERVSKEmkrgdig 99   Plasmodium fa...
CAK64719       30 NSTLIILAETGSGKTTQIPQYLIEAGygg--------------------edRVLVSLPRKMAAISIAQRVSDEngte-lg 88   Paramecium te...
XP_003240013   21 FDVILIKGEAGCGKTTIIPTILCKKNls----------------------kKMVVSQTKKIAVFNAVSYMSKKmniq-ig 77   Cryptomonas p...
Q8TE96         63 TGVVLVSGEPGSGKSTQIPQWCAEFAlarg-----------------fqkgQVTVTQPYPLAARSLALRVADEmdlt-lg 124  human
EGH38505       35 ASQVLLSAPTGAGKSTWLPLQLLAHPgi---------------------ngKIILLEPRRLAARNVAQRLAELlnek-pg 92   Escherichia c...
NP_001088262   80 NQIVVVSAGPKSGKSSQIPQWCAEYClagh-----------------yqhgAVVCTQAHKQTAVWLAMRVADEmdvn-ig 141  African clawe...
ADT87324       19 HDHVIVEAETGSGKSTCLPCWAAEQG-------------------------RVLVIEPRRIACTSLAEFLAQQrqea-vg 72   Vibrio furnis...

Feature 1                                                       ##                                
3LLM_A        139 kSCGYSVRFESILPrphaSIXFCTVGVLLRKLeagi--rgiSHVIVDEIHERDintDFLLVVLRDVVQay-----peVRI 211  human
XP_011523555  128 sKVGYQVRFDDCSSke-tAIKYMTDGCLLKHIlgdpnltkfSVIILDEAHERTlttDILFGLLKKLFQekspnrkehLKV 206  human
NP_415931     152 gCIGYKVRFSDHVSdn-tMVKLMTDGILLAEIqqdrllmqyDTIIIDEAHERSlniDFLLGYLKELLPrr-----pdLKI 225  Enterobacteri...
XP_001349312  100 nYVGYTIRFKNVCSdk-tRIKFVTDGILIREImndpllkkyKFLILDEIHERSirtDVLLGYTKILLQkr-----kkIKI 173  Plasmodium fa...
CAK64719       89 qDIGYRVRFESKVSen-tKIEYVTDGTLIQIImgnpliegySVVMLDDIHERTlntDLLLCLIKKIQKkr-----peLKV 162  Paramecium te...
XP_003240013   78 qQIGYTVRFEHKSTkk-tKIKFVTDGILFKEIlenfflleyDCIILDEFHERTvytDFLLASLKQIKKir-----tdLKI 151  Cryptomonas p...
Q8TE96        125 hEVGYSIPQEDCTGpn-tLLRFCWDRLLLQEVastrgtgawGVLVLDEAQERSvasDSLQGLLQDARLekl---pgdLRV 200  human
EGH38505       93 dTVGYRMRAQNCVGpn-tRLEVVTEGVLTRMIlrdpelsgvGLVILDEFHERSlqaDLALALLLDVQQglr----ddLKL 167  Escherichia c...
NP_001088262  142 hEVGYIVPFENCCTse-tILRYCTDEMLRREMmsnpllssyGVVIIDDVYERFvstDVLLSFLKVIAVsr-----peLKV 215  African clawe...
ADT87324       73 qHIGYAIKLENRSSeq-sQVVFVTPGVALRWFaedg-lksfDVIMVDEFHERRwdtDLLVALLKARQR---------HRL 141  Vibrio furnis...

Feature 1                                  
3LLM_A        212 VLXSATidTSXFCEYFfn-cPIIEV 235  human
XP_011523555  207 VVMSATmeLAKLSAFFgn-cPIFDI 230  human
NP_415931     226 IITSATidPERFSRHFnn-aPIIEV 249  Enterobacteriaceae
XP_001349312  174 ILMSATfdINIFNQFFnn-pPIITI 197  Plasmodium falciparum 3D7
CAK64719      163 IVSSATmeVDLLQNFFpn-sKIIAI 186  Paramecium tetraurelia
XP_003240013  152 IIMSASgeYVKIAKFFnsklGKITI 176  Cryptomonas paramecium
Q8TE96        201 VVVTDPalEPKLRAFWgn-pPIVHI 224  human
EGH38505      168 LIMSATldNDRLQQMLpe-aPVVIS 191  Escherichia coli AA86
NP_001088262  216 VIITCPslSGTLVSYYgn-aPLVEA 239  African clawed frog
ADT87324      142 VVTSATleGERLATYLq--aKRLQA 164  Vibrio furnissii NCTC 11218

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap