3LFU,2WJV,1W36,4N0O,4PJ3,3PJR


Conserved Protein Domain Family
DExxQc_SF1-N

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cd17914: DExxQc_SF1-N 
Click on image for an interactive view with Cn3D
DEXQ-box helicase domain of superfamily 1 helicase
The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 438706
Aligned: 7 rows
Threshold Bit Score: 100.638
Created: 19-Jul-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingDEAD box
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:4PJ3: Human RNA helicase Aquarius binds Mg.AMP-PNP, contacts at 4A
  • Comment:Walker A motif or motif I
  • Structure:3PJR: Geobacillus stearothermophilus helicase binds ATP, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #######                                                                  
3LFU_A      24 NLLVLAGAGSGKTRVLVHRIAwlmsve-----ncspysIMAVTFTNkAAAEMrhrigqlmgtsqggmwvgtfhglahrll 98  
2WJV_A     373 LSLIQGPPGTGKTVTSATIVYhlarq--------gngpVLVCAPSNiAVDQLtekihqtglkvvrlcaksreaidspvsf 444  human
1W36_D     166 ISVISGGPGTGKTTTVAKLLAaliqma-----dgercrIRLAAPTGkAAARLteslgkalrqlpltdeqkkripedas-- 238  Escherichia coli
4N0O_A     174 SEYVEGPPGSGKTFHLVKDVLavv------------gsATLVVPTHaSMLDCinklkqagadpyfvvpkytvl------- 234  Equine arteritis...
Q8R151     607 LAIIQGPPGTGKTYVGLKIVQalltnksvwqintqtfpILVVCYTNhALDQFlegiygcqktsivrvggrsnseilkqft 686  house mouse
4PJ3_A     800 LTXVVGPPGTGKTDVAVQIISniyhn-------fpeqrTLIVTHSNqALNQLfekixaldiderhllrlghgeeeletek 872  human
3PJR_A      26 PLLIMAGAGSGKTRVLTHRIAylmaek-----hvapwnILAITFTNkAAREMrervqsllggaaedvwistfhsmcvril 100  Geobacillus stea...
Feature 1                                                                                      
3LFU_A      99 rahhmdanlpqdfqildsedqlrllkrlikamnldekqwpprqa------------------------------------ 142 
2WJV_A     445 lalhnqirnmdsmpelqklqql---------------------------------------------------------- 466  human
1W36_D         --------------------------------------------------------------------------------      Escherichia coli
4N0O_A         --------------------------------------------------------------------------------      Equine arteritis...
Q8R151     687 lrelrnkrefrrtlpmhlrraymsivtemkeseqklqegaqtlectmhgvlreqhlekyisaqhweslmsgpvqdadwvc 766  house mouse
4PJ3_A     873 dfsrygrvnyvlarrielleevkrlqkslgvpgdasytcetagyfflyqvxsrweeyiskvknkgstlp----------- 941  human
3PJR_A     101 rrdidriginrnfsildptdqlsvmktilkeknidpkkfeprtil----------------------------------- 145  Geobacillus stea...
Feature 1                                                                                      
3LFU_A         --------------------------------------------------------------------------------     
2WJV_A         --------------------------------------------------------------------------------      human
1W36_D         --------------------------------------------------------------------------------      Escherichia coli
4N0O_A         --------------------------------------------------------------------------------      Equine arteritis...
Q8R151     767 vqpskhsmilewlglgvgsftqsaspagpentaqaegeeeeegeeegslieiaeeadliqadrvieeeevvrprrrkkee 846  house mouse
4PJ3_A         --------------------------------------------------------------------------------      human
3PJR_A         --------------------------------------------------------------------------------      Geobacillus stea...
Feature 1                                                                                      
3LFU_A     143 ---------------------------------------------------------------------------mwyin 147 
2WJV_A         --------------------------------------------------------------------------------      human
1W36_D         --------------------------------------------------------------------------------      Escherichia coli
4N0O_A         --------------------------------------------------------------------------------      Equine arteritis...
Q8R151     847 ngtdqelakmllamrldqevpgttagpeqateewqtqrgqkkkmkrrvkvelrklntmtkaeangiqdvwqldlssrwql 926  house mouse
4PJ3_A     942 --------------------------------------------------dvtevstffpfheyfanapqpifkgrsyee 971  human
3PJR_A     146 ---------------------------------------------------------------------------gtisa 150  Geobacillus stea...
Feature 1                                                                                      
3LFU_A     148 sqkdeglrphhiqsygnpveqtwqkvyqayqeacdraglvdfaelllrahelwlnkphilqhyrerfTNILVDEFQDtnn 227 
2WJV_A     467 -----------------kdetgelssadekryralkrtaerellmnadvicctcvgagdprlakmqfRSILIDESTQate 529  human
1W36_D     239 ------------------------------------------tlhrllgaqpgsqrlrhhagnplhlDVLVVDEASMidl 276  Escherichia coli
4N0O_A     235 ----------------------------------------------dfprpgsgnitvrlpqvgtseGETFVDEVAYfsp 268  Equine arteritis...
Q8R151     927 yrlwlqmyqadtrrrilsyerqyrtwaermaelrlqedlhilkdaevvgmtttgaakyrqilqqvepRIVIVEEAAEvle 1006 house mouse
4PJ3_A     972 dxeiaegcfrhikkiftqleefrasellrsgldrskyllvkeakiiaxtcthaalkrhdlvklgfkyDNILXEEAAQile 1051 human
3PJR_A     151 aknellppeqfakrastyyekvvsdvyqeyqqrllrnhsldfddlimttiqlfdrvpdvlhyyqykfQYIHIDEYQDtnr 230  Geobacillus stea...
Feature 1                                   #                                                  
3LFU_A     228 iqyaw------irllagdtGKVMIVGDDDQsiygwrgaqven---------------------------iqrflndfpga 274 
2WJV_A     530 pecm--------vpvvlgaKQLILVGDHCQlgpvvmckkaakagl----------------------sqslferlvvlgi 579  human
1W36_D     277 pmmsr------lidalpdhARVIFLGDRDQlasveagavlgdicayanagftaerarqlsrltgthvpagtgteaaslrd 350  Escherichia coli
4N0O_A     269 vdl----------ariltqGRVKGYGDLNQlgcvgpasvp-------------------------------rnlwlrhfv 307  Equine arteritis...
Q8R151    1007 ahti--------atlskacQHLILIGDHQQlrpsanvydlaknfn---------------------levslferlvkvni 1057 house mouse
4PJ3_A    1052 ietfiplllqnpqdgfsrlKRWIXIGDHHQlppviknxafqkysn---------------------xeqslftrfvrvgv 1110 human
3PJR_A     231 aqytl------vkklaerfQNICAVGDADQsiyrwrgadiqn---------------------------ilsferdypna 277  Geobacillus stea...
Feature 1               
3LFU_A     275 eTIRLEQNY 283 
2WJV_A     580 rPIRLQVQY 588  human
1W36_D     351 sLCLLQKSY 359  Escherichia coli
4N0O_A     308 sLEPLRVCH 316  Equine arteritis virus Bucyrus
Q8R151    1058 pFVRLNYQH 1066 house mouse
4PJ3_A    1111 pTVDLDAQG 1119 human
3PJR_A     278 kVILLEQNY 286  Geobacillus stearothermophilus

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