Conserved Protein Domain Family
BRCT_microcephalin_rpt3
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cd17751: BRCT_microcephalin_rpt3 
third BRCT domain of microcephalin and similar proteins
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the third repeat.
Links
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Statistics
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PSSM-Id: 349382
Aligned: 30 rows
Threshold Bit Score: 53.0055
Created: 8-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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BRCT sequence
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [SC]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q8NEM0        749 GPYRGTLFAd----------QPAMFVSPASS------PPVAKLCELVh--LCGGRVSQVPRq-ASIVIGPysgk------ 803  human
OAF67641      814 KNYLNNLFSn----------VGSMYLFIDSK------HVKDSFNLILk--KCGGKISNNRVr-ADICIGKyc-------- 866  Intoshia linei
XP_657394     496 QQRLNNVQLl---------tGLRVYLSSFPKke---vIGFKKLEYIFllrQCGAKIVKDKKe-SDISIGF---------- 552  Entamoeba his...
CEO95647      288 DGDHRGMFA-----------GELVFVDDDVE------PPKQTIQELFl--ACGAQIVQKPAd-ASVCIGAg--------- 338  Plasmodiophor...
CCI49677      420 QRPSCQIFA-----------NLKFFVGSNVA------PSRKTLQTLIq--CAGGEISNQIIk-ANYSVCEdgsfsr--rl 477  Albugo candida
XP_001453079  211 SRTRGGMYDfl-------rnYEFTIEVGNVNkt---iINQEYVETLIl--LCGGNIVNQKEktQNTIIIKivqdpqmnht 278  Paramecium te...
EIE88916      304 WYPRANIARq----------HLPFMPSTTCIkvnsvsAGKEFTEQLVr--LAGGHVVKEMEe-ANVVISNepl------- 363  Rhizopus dele...
XP_018297010  354 SRKREPLFPs----------NLQVFIFSLQV------VDRPLAETLIt--QGGAKVARRMEd-ADILITPrpl------- 407  Phycomyces bl...
ORZ15071      557 SSYEAILYFpraraarrrdpLLPSTISIYIRst---tLPLDLAQQLVk--KAGGYVVDNMKe-ADIVISRtsi------- 623  Absidia repens
XP_004358612  582 AHETGELLLs----------GKSFYLDGKVKdv---hLNKQKKKQLIt--QLGGTISKTFEn-CDICLFSgdsste--ne 643  Dictyostelium...

Feature 1                     #   #      
Q8NEM0        804 kkaTVKYLSE-KWVLDSITQHKV 825  human
OAF67641      867 -qkSKFSVIT-KWIVDCIMYAKV 887  Intoshia linei
XP_657394     553 ---EKGSIQC-DWLFDSICNNCQ 571  Entamoeba histolytica HM-1:IMSS
CEO95647      339 --pSTGTVDV-KWLFDSLIAFKK 358  Plasmodiophora brassicae
CCI49677      478 rntSSLVVTG-KWVFDSVANLAL 499  Albugo candida
XP_001453079  279 rieCIPMIVNqKWLFDSISKFNM 301  Paramecium tetraurelia strain d4-2
EIE88916      364 -qiDKIVVSE-SWLYESIEQWTS 384  Rhizopus delemar RA 99-880
XP_018297010  408 -nvDKDLAIE-NWLLECIENWQY 428  Phycomyces blakesleeanus NRRL 1555(-)
ORZ15071      624 -dsDIMTVTE-NWLLDSIEHWRY 644  Absidia repens
XP_004358612  644 pgsGKPIVDD-RWLYESIAEYSI 665  Dictyostelium fasciculatum

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