second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins
Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.
Feature 1:Crb2 interaction site [polypeptide binding site]
Evidence:
Structure:4BU1: Schizosaccharomyces pombe Rad4 dimer in complex with two Crb2 phosphopeptides through its BRCT1/2 domain, contacts at 4A.
Comment:Rad4(TopBP1) facilitates activation of the DNA damage checkpoint by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Jiyao W et al.(2023). "The conserved domain database in 2023.",