3SZM,3SHT


Conserved Protein Domain Family
BRCT_microcephalin_rpt2

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cd17736: BRCT_microcephalin_rpt2 
second BRCT domain of microcephalin and similar proteins
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.
Statistics
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PSSM-Id: 349368
Aligned: 39 rows
Threshold Bit Score: 78.4003
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [SC]Click to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
3SZM_A         12 RTLVMTSmp---sEKQNVVIQVVDkl----------kGFSIAPDvc--etTTHVLSGkp------lRTLNVLLGIARGCW 70   human
XP_005644814  333 GFLSLTAve---eGTAELAAAAVKrl----------rRLRMCPEgrd-emATHLIVGsq------kRTLKVMLAIAKGAW 392  Coccomyxa sub...
CCI49677      317 FIISMSAie---pADRVTLEKAINsvdsvyanvqgyrKTRVIRSsevsvpFTHLIIGkd-----trRTLKVLFGLARGAW 388  Albugo candida
KXZ55564      110 KYLAHTCid---aAVASTIHSAVRql----------gNARLCTPgyedghITHLVVGeq-----qrRTIKVLLGIANGAL 171  Gonium pectorale
CEO95647      194 CSIALSQvd---dFVRDAAEDLAKnl----------pGYAVCDSv----dFTHLVVGka------aRTVKVFYAIARGAW 250  Plasmodiophor...
XP_020435658  791 ERLVCISavddidEKKELAESIAQl-----------kGSDLTDNvn---eFTHLVLGnq-----nlRTIKFFYAMASGRW 851  Polysphondyli...
XP_004358612  490 KIIAMTLvp---dTAKDMLKGHIRs-----------lEATYTDDet---iFTHLILGds------kRTVKVLNAMAAGTW 546  Dictyostelium...
CEO95977      441 FVVLYTSlh---dDEFDLLQSLSIae---------asRMRLETMmt--ddVTHLVVRtgadrvasaRTIKYMYAVAKGVW 506  Plasmodiophor...
XP_001736960  261 IIIHLSGis---kETRESLSEEIMk-----------kGFEISLNys--nkVTHVVVSs-------kLTMTSIKALIEGKW 317  Entamoeba dis...
OAF67641      716 KNVIFTSfh---kPKLLMLKHKIMsn---------leNVSFSENfdl-nkTTHIICAsd------sRTINFVFGVIYGLW 776  Intoshia linei
Feature 1              #   #       
3SZM_A         71 VLSYDWVLWSLELGHWI 87   human
XP_005644814  393 LLSPAWLTASLEAGKWQ 409  Coccomyxa subellipsoidea C-169
CCI49677      389 ILSDAWILASLSSGRWL 405  Albugo candida
KXZ55564      172 LVTPAWVTESLAAGCWL 188  Gonium pectorale
CEO95647      251 ILSSDWILQSLQAGKWL 267  Plasmodiophora brassicae
XP_020435658  852 ILTPAWVTESRKQGKWL 868  Polysphondylium pallidum PN500
XP_004358612  547 ILTSSWITESSTKGEWL 563  Dictyostelium fasciculatum
CEO95977      507 CCSFQWIRDWIRWSTPP 523  Plasmodiophora brassicae
XP_001736960  318 VVSKNWIINGMKKDEFK 334  Entamoeba dispar SAW760
OAF67641      777 IVSDRWILDSIKQSKFC 793  Intoshia linei

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