Conserved Protein Domain Family
BRCT_PARP4_like
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cd17726: BRCT_PARP4_like 
BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins
PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.
Links
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Statistics
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PSSM-Id: 349358
Aligned: 14 rows
Threshold Bit Score: 119.315
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9UKK3          5 IFANCIFCLKVKYLp--qQQKKKLQTDIKENGGKFSFSLnpQCTHIILDna-dvLSQYQLNSIQKnHVHIANpDFIWKSI 81   human
NP_001164635    3 IFANCVFFIKLKYSs--iQKKNSLKACIEENGGAIDFVLnnKCTHVLVDna-nvLSHHNLKITQKyQLPVLYaDFVWKSV 79   chicken
XP_017947343    5 FFSDSVFFLKLNDLs--fDERKAIKFIITSNGGVISFVLnqKCTHVVVNti-gcLSSSQQKNVQQhQIPIVDsHFIWQCL 81   tropical claw...
XP_021327825   62 VFENCTVVFDVKNVp--fKEKQKLKSALLENGGNISYTInkECSFVVTSsv-ndLSSNRQRSIQKlQIPVVGtQYVWSCV 138  zebrafish
XP_006006748    3 IFRNWVLFLELKTLp--iKEKSKLKQLIKENGGTISYVInqKCTHVIGNdc-dtLSPWLLKKIQKyEIPVLSvKYVLKCI 79   coelacanth
EKC27907       40 VLAGCQIVLDLSTSvg-fKKKQEVRSTVTQNGGVISYIVtkKSTHVVLNdaekaDVSYKCKMAAKfRIPVVSlDFIFDCI 118  Pacific oyster
XP_019851276    7 LFRGCQITLELDSSip-fKKKSALKQSVIQYGGIVSFIVtkKTTHLVVNnvekaQDSYKSRMAQKwGIPVVSiKFIEDCI 85   Amphimedon qu...
XP_013073921    3 IFKGIQIAADFGYNlg-fKKKLELRKKIVENGGIISFIVtkKCHFVVTSdpekcQLSTKCRMASKyGLPVLNlDYIWDCL 81   Biomphalaria ...
XP_002608764    3 VFRGCQVTLELTGVtlpyKEKKRLRELVTQNDGIISYIInkKTSFLVLGnk-erTDSYKCRTAVKlGLPVVSlEYIEACV 81   Florida lancelet
XP_783893       4 VFDKCQIVFDLDAIkvsyKVRQGLKTKITHHSGTVAYSLnnKTTHMIVDeskrgGFSHKCNKAQKlNIPIVGtSYLDDCV 83   purple sea ur...

Q9UKK3         82 REKRLLD 88   human
NP_001164635   80 ENGKLLV 86   chicken
XP_017947343   82 EKKCLIQ 88   tropical clawed frog
XP_021327825  139 DEGHLLP 145  zebrafish
XP_006006748   80 EEGRVLE 86   coelacanth
EKC27907      119 SQGKLLD 125  Pacific oyster
XP_019851276   86 ENGKLLE 92   Amphimedon queenslandica
XP_013073921   82 QVEKLLP 88   Biomphalaria glabrata
XP_002608764   82 QTGELLH 88   Florida lancelet
XP_783893      84 AASRLLN 90   purple sea urchin
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