3SQD


Conserved Protein Domain Family
BRCT_PAXIP1_rpt5
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cd17712: BRCT_PAXIP1_rpt5 
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins
PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.
Links
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Statistics
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PSSM-Id: 349344
Aligned: 22 rows
Threshold Bit Score: 104.242
Created: 14-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [SC]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                         #   #       
3SQD_A         16 TPFVLFTGFEpvqvQQYIKKLYILGGEVAESAq-KCTHLIASKVtRTVKFLTAISVVKHIVTPEWLEECFRCQKFI 90   human
EKC19013      618 QPVIIFTGFPkgqvRKFQTVVSQLGGISTENPr-LCTHLVAPSLsRTMKFFVAINVCKHVVTGDWIEACLAQGAFV 692  Pacific oyster
ELU01586      761 APSVLITGMVfsqaKAIRADIEGLGGRVVTSSs-EATHMVCPQVmRTVKFLTALSMVQHIVSPAWVHCSTKQGHFV 835  Capitella teleta
KJE89512      764 VPRVMFTGVDn---PKYNNIVTELGGTLITSSvlDCDHLVTDNVrRTVKFLAGIGVCHHIVSLGWLDASHRSGRFV 836  Capsaspora owczar...
CEP02140      451 SPVIMFTGIAt---EDLQQMVQVLGGVLTEEPg-AATVLVCDHVrRTVKFLCAISTAKHIVNEQWLLDSAAQKHFL 522  Plasmodiophora br...
XP_013410668  725 APVVIFTGIPkgrmTKMEEQVEALGGTVTTDPa-AATHLVTNQLaRTVKFLICINTCQHIVTTQWLDQSSIQGHFL 799  Lingula anatina
XP_015757567  515 GPRVLFTGIPpsevSRLVELIIELGGTVVGSVm-QCTHLVTRKIiRTVKFLCAISVAQYVVTPEWINKSHQSKRFL 589  Acropora digitifera
XP_001750026  409 KPRVAFTSIPsndrRRFEHIVWTLGGEVVSAE--ESTHLVVGAPsRTANFLKALCVSDHILEVSWLEDCNASYKFL 482  Monosiga brevicol...
CRK86347     1232 IPIVMLSQVDd--eDGLTRAITILGGRVTKDHa-EMTHLVMTKPsRTVKFLYALCRAKYIVNSSWLEESAKQGFFQ 1304 Clunio marinus
NP_729947    2075 PPKVIFSQVAd--aEALKKAVLILGGIVVDSPa-DATHLVMTREsRTCKLIQACCHVDYVLKSSWIADSAKAGKFV 2147 fruit fly

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