Conserved Protein Domain Family
RUN_SGSM2
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cd17704: RUN_SGSM2 
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins
SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.
Links
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Statistics
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PSSM-Id: 439066
Aligned: 5 rows
Threshold Bit Score: 360.017
Created: 10-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O43147         18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRsDKMAALFTKVGKTCPvaGEICHKVQELQ-QQA 96   human
XP_009289984   19 REVKQIMEEAVTKKFVHEDSSHIIALCSSIEACLSHLLKRRAAGFLRsDKIAALFTKIGKVNTtvSEICRKVQEQLqQQA 98   zebrafish
XP_002935339   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRsDKVAALFMKVAKTCAtaADICKKVQDLQ-QQV 96   tropical claw...
XP_004946852   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHMLKRRAAGFLRtDKVAALFTKVGKTYAiaGDICKKVQELQ-QQV 96   chicken
XP_007898990   18 REVKQIMEEAVTKKFVHEDSSHIIALCSVVEACLLHTLKRRAAGFLRsDKVAALFTKVGKTYPiaGDVCKKVQELL-QQV 96   elephant shark

O43147         97 EGRKpsgvsqealrrq--gsasgkapalspQALKHVWVRTALIEKVLDKVVQYLAENcSKYYEKEALLADpVFGPILASL 174  human
XP_009289984   99 EITRrtqstgqeslrrqgsstgrapqplsaQAIKHIWVRTALFEKVLDKIVQYIVDNaSKYYEREALMHDsVFGPILAAL 178  zebrafish
XP_002935339   97 EGRKnissgqeslkrq--ssttgrtvtltpQALKHIWVRTALIEKVLDKIVQYIVDNcSKYYEKESLMSDpVCGPILAAL 174  tropical claw...
XP_004946852   97 ESRKnqpnvqeplkrq--gsatsktpvltpQAIKHIWVRTALIEKVLDKIVQYIVDNcSKYYEKEALLADpVCGPILASL 174  chicken
XP_007898990   97 DKKNqnngqeslkrq----gsvsknpiltpQAIKHIWVRTALFEKVLDRIVQHLVDNsSKYYEQEALMSDrVCGPILASL 172  elephant shark

O43147        175 LVGPCALEYTKLKTADHYWTDPS 197  human
XP_009289984  179 LVGPCALEYTKLKTSDHFWTDPS 201  zebrafish
XP_002935339  175 LVGPCALEYTKLKTADHYWTDPS 197  tropical clawed frog
XP_004946852  175 LVGPCALEYTKLKTADHYWTDPS 197  chicken
XP_007898990  173 LVGPCALEYTKLKTADHYWTDPS 195  elephant shark
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