Conserved Protein Domain Family
RUN_SGSM1
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cd17703: RUN_SGSM1 
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins
SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.
Links
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Statistics
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PSSM-Id: 439065
Aligned: 6 rows
Threshold Bit Score: 381.664
Created: 10-Mar-2016
Updated: 13-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2NKQ1         20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPpAEDLSRKVQDLEQLIE 99   human
Q4RSW6          9 PQVKQIMEEAVTRKFVHEDSSHIVSFCAAVEACVLHGLKRRAAGFLRSNKVAALFMKVGKSFApAEELCKKAQELEQVLG 88   spotted green...
NP_001106422   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLYGLKRRAAGFLRSNKIAALFMKVAKSFPlAEELCRKVQDLEQLLE 99   western clawe...
XP_007900124   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLYGLRRRAAGFLRSNKIAALFMKVSKSFPpAEELCRRVQELEQLLD 99   elephant shark
XP_005999497   20 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIEALFMKVGKSFPlAEELCRKVQEFEQLIE 99   coelacanth
KFQ36161        1 QQVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLYGLKRRAAGFLRSNKIAALFMKVGKSFPlAEELCKKVQDLEQLIE 80   brown roatelo

Q2NKQ1        100 SARNQiqglqenvrklpklPNLSPLAIKHLWIRTALFEKvLDKIVHYLVENssKYYEKEALLMDpVDGPILASLLVGPCA 179  human
Q4RSW6         89 TKRSQslqsqeslrkmprlPTLGPQGVKNLWIRAALFEKvLDKIVLYLVENssKYYEKEALLMDpVDGPILASLLVGPCA 168  spotted green...
NP_001106422  100 NKRNQmqgvqesvrkaqklPNLSPQAIKHLWIRTALIEKvLDKIVLYLVENcnKYYEKEALLMDpVDGPILASLLVGPCA 179  western clawe...
XP_007900124  100 SRKHQgsglpdplrrpqkaPSLSPQALKHLWIRTALFEKlLDKIVQHLVENssKYYEKEALLMDaVDGAILGSLLVGPCA 179  elephant shark
XP_005999497  100 NKRNQmpvsqentrklpklPNLSPQAMKHLWIRIALFEKvLDKIVHYLVENssKYYEKEALLMDpVDGPILASLLVGPCA 179  coelacanth
KFQ36161       81 NARNQvqgipenvrkmpklPNLSPQAIKHLWIRTALFEKvLDKIVHYLVENssKYYEKEALLMDpVDGPILASLLVGPCA 160  brown roatelo

Q2NKQ1        180 LEYTKMKTADHFWTDPS 196  human
Q4RSW6        169 LEYTKMKTADHLWTDPS 185  spotted green pufferfish
NP_001106422  180 LEYTKMKTADHFWTDPS 196  western clawed frog
XP_007900124  180 LEYTKMKTADHFWTDPS 196  elephant shark
XP_005999497  180 LEYTKMKTADHFWTDPS 196  coelacanth
KFQ36161      161 LEYTKMKTADHFWTDPS 177  brown roatelo
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