6IF2


Conserved Protein Domain Family
RUN_RUSC2
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cd17702: RUN_RUSC2 
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RUN domain found in RUN and SH3 domain-containing protein 2 (RUSC2) and similar proteins
RUSC2, also called iporin, or interacting protein of Rab1, is a novel interacting molecule for the active GTP-bound conformation of Rab1. It may function as a link between the targeting of endoplasmic reticulum derived vesicles, triggered by the Rab1 GTPase and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions. This model contains the RUN domain of RUSC2.
Links
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Statistics
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PSSM-Id: 439064
Aligned: 8 rows
Threshold Bit Score: 293.654
Created: 10-Mar-2016
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:6IF2: Human RUSC2 binds Rab35, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #   #  #    # #                                                        
6IF2_A         16 QKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSsvSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDViIGQRKNMPWSV 95   human
KFP63210     1021 QKKGLVKAINIAVDLIVAHFGTSRDPGVKAKLGNSsvSPNVGHLILKYLCPAVRDILSDGLKAYVLDMiIGQRRNIPWSV 1100 red-legged se...
XP_007890411  695 QKKGLVKAVNTAVDLIVAHFGTSREPGVKAKLGNSsvSPNVGHLILKYLCPAMRNILQDGLKAYVLDViVGQRKNLPWTV 774  elephant shark
Q4RUZ1       1027 QKRGLVKAVNTAVDLIVAHFGTSRDPDVKAKLGNSwvSPNVGHLILKYLCPALHEVLQDGLKPYVLDLiIGQRRCQPWSL 1106 spotted green...
XP_005155711  818 HKRSMLKAVSLAVNDITAHFNSRRDPEEKIRLGNSllCSTINHLVLKQLYPRIQNILQDGLKAYTLDLiIGQRRNKLWNV 897  zebrafish
ANV20926      996 QKRGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSsvSPNIGHLILKYLCPAVRDILSDGLKPWVLDViVGQRRNLPWTV 1075 African clawe...
XP_014350657  968 QKKGLVKAINTAVDLIVAHFGTSRDPGVKAKLGNSsvSPNVGHLILKYLCPAIRDILGDGLKAYVLDMiIGQRRNVPWSV 1047 coelacanth
Q8N2Y8        992 QKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSsvSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDViIGQRKNMPWSV 1071 human

Feature 1                                                        #                                
6IF2_A         96 VEASTQLGPSTkvLHGLYNKVSQFPELtshTMRFNAFILGLLNIRsLEFWFNHLYNHEDIIQTHYQPWGFLSaaht-vcp 174  human
KFP63210     1101 VEASTQLGPSTklLHSLYSKISQYTELtshTMRFNAFIFGLLNIRsLEFWFNHLYNHEDIILAHYQPVGFLClshs-vcq 1179 red-legged se...
XP_007890411  775 IEASTQLGPSTkaLNNLFCKISQYTELtnhSIRFNAFIFGLLNIRsLEFWFNHLNNHEDIIGVHYLPTGFLAlshs-vcq 853  elephant shark
Q4RUZ1       1107 AEASTQLGPSTrvLHSLFSKVSQYSELtnhSLRLNSFIFGLLNLKsLEFWFSHLYTHDDIIAAHYNPWGFLPlsqg-vcq 1185 spotted green...
XP_005155711  898 IEATAQPGSSTrlPDSLVSVVKRCSHIp-sHKRLSVFFTDLLNLRaLEFWIHHLYTSIDVVTEHYYQWGFLAlaqgptyg 976  zebrafish
ANV20926     1076 VEASTQLGPSTklLHSLCCKVNQYSELsshNLRFNAFIFGLLNIRsVEFWFNHLYNHEDIIFSHYEPVGFLSvshg-vcq 1154 African clawe...
XP_014350657 1048 VEASTQLGPSTklLHSLVCKISQYAELtnhSMRFNAFIFGLLNIRsLEFWFNHLYTHEDIVSVHYQPSGFLAlahs-vcq 1126 coelacanth
Q8N2Y8       1072 VEASTQLGPSTkvLHGLYNKVSQFPELtshTMRFNAFILGLLNIRsLEFWFNHLYNHEDIIQTHYQPWGFLSaaht-vcp 1150 human

Feature 1             #  ## ##  ##        
6IF2_A        175 gLFEELLLLLQPLALLPFSLDLLF 198  human
KFP63210     1180 pLFEELLLLLQPLSLLPFNLDLLF 1203 red-legged seriema
XP_007890411  854 pLFEELLLLLQPLSLLPFDLDLMF 877  elephant shark
Q4RUZ1       1186 pLFEELLLLLQPLSLLPFDLDLLF 1209 spotted green pufferfish
XP_005155711  977 pLFQEMLLLLQPLSLLPFDLHLPF 1000 zebrafish
ANV20926     1155 mLFEELLLLLQPLSLLPFDLDLLF 1178 African clawed frog
XP_014350657 1127 pLFEELLLLLQPLSLLPFDLDLLF 1150 coelacanth
Q8N2Y8       1151 gLFEELLLLLQPLALLPFSLDLLF 1174 human

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