Conserved Protein Domain Family
RUN_RUFY4
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cd17697: RUN_RUFY4 
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins
RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. RUFY4 belongs to the FUFY protein family which is characterized by the presence of an N-terminal RUN domain and a C-terminal FYVE domain; this model represents the RUN domain of RUFY4.
Links
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Statistics
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PSSM-Id: 439059
Aligned: 4 rows
Threshold Bit Score: 265.506
Created: 10-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6ZNE9         13 DLRAAVSAILQGYGDgqgpvt-dtsaeLHRLCGCLELLLQFDQKEQKSFLGPRKDYWDFLCTAlrrqrgnmEPIHFVRSQ 91   human
XP_006008387   14 KDLQSIILELQEEHReksspindgspaLHRLCAKLEYLLQFDQKEKKSFFGNRRDYWDYICCCigkkkggnDGVHFVSSI 93   coelacanth
OWK63172       12 KDLQKTVAELKCSYQeqnlpvtdgsreLHSLCAQLEFLLQFDLKEKRSFFGQRKDYWDFLCQGlarcrqehEGIHFVTSL 91   Bengalese finch
XP_020389557   14 KDLQASIEELRKDQErnqlpitdanpvLHGLCTRLEYLLQYDQKEKKTMFGSRKDYWDYISLClnshkcgtNAVQFINHT 93   whale shark

Q6ZNE9         92 dklkTPLGKGRAFIRFCLARGqLAEALQLCLLNseltreWYGPRSPLLcpERQEDILDSLYALNGVAFEL 161  human
XP_006008387   94 pelkTSLGKGRAFIRCCLVQKqLAESLQLCTVDpnitsdWYYARSPLLnkELTSTIISHLYELNGINFKL 163  coelacanth
OWK63172       92 dklkTPVGRGRAFLRYCLVHRqLAESLQLCLLDpeslceWYYARSPFLspKQRAEILGSLYELDCVTFHL 161  Bengalese finch
XP_020389557   94 tqlnTSLGKGRAFIRYCLVQQkLADSLQLCFLNqqlvgdWYYARSPFLsdRLRSDIVDKLYSLNEINFDL 163  whale shark
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