Conserved Protein Domain Family
RUN_RUFY2
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cd17695: RUN_RUFY2 
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.
Links
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Statistics
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PSSM-Id: 439057
Aligned: 7 rows
Threshold Bit Score: 332.328
Created: 10-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8WXA3        10 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLsyNKTIWGPLELVEKLyPEAEEIG 89  human
XP_421568     10 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLsyNKTIWGPLELVEKLyPEAEEIA 89  chicken
NP_001231848 100 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVKKSFLgyNKSLWGPLEMVEKLcPEAGEIA 179 zebrafish
NP_001016214  34 ERTNLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKTFLsfNKTIWGPLEIVEKLcPEAEEIA 113 western clawed ...
XP_014340480 118 ERANLLNMAKLSIKGLIESALRFGRTLDSDYPPLQQFFVVMEHCLKHGLKVKKSFLgySKSIWAPMELVEKLcPEAGEIA 197 coelacanth
XP_007902741  15 ERANLLNMANLSIKGLIESALSFGRTLDSDYAPLQQFFVVMEHCLKHGLKVKKSFLghNKSLWGPLELVEKLcPEAGEVV 94  elephant shark
Q8WXA3        59 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLsyNKTIWGPLELVEKLyPEAEEIG 138 human

Q8WXA3        90 ASVRDLPGLkTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLC 165 human
XP_421568     90 ASVRDLPGLkTPLGRARAWLRLALMQKKMADYLRCLIIQRELLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLC 165 chicken
NP_001231848 180 ASVRDLPGLkTPLGRARAWLRLALMQKKLADYLRLLITRKDILSEFYESSAVMLEEEGAVIVGLLVGLNVIDANLC 255 zebrafish
NP_001016214 114 ASVRDLPGLrTPLGRARAWLRLAMMQKKLADYLRCLIMRRDLLSDFYENHAVMMEEEGTVIVGMLVGLNVIDANLC 189 western clawed frog
XP_014340480 198 ASVRDLPGLkTPLGRVRAWLRLALMQKKLADYLRCLITRKDLLSDFYDYHALMMEEEGAVIVGLLVGLNVIDANLC 273 coelacanth
XP_007902741  95 ASVRDLPGLkTPLGRARAWLRLAMMQKKLADYLRCLMIRKDLLSEFYEDTALIMEEEGAVIVGLLVGLNVIDANLC 170 elephant shark
Q8WXA3       139 ASVRDLPGLkTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLC 214 human
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