Conserved Protein Domain Family
RUN2_DENND5B
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cd17693: RUN2_DENND5B 
RUN2 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins
DENND5B, also called Rab6-interacting protein 1 (Rab6IP1)-like protein, functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the second RUN domain of DENND5B.
Links
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Statistics
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PSSM-Id: 439055
Aligned: 5 rows
Threshold Bit Score: 334.887
Created: 14-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6ZUT9       1091 QIQEGIGEAVNNIVKHFHKpekergsLTVLLCGENGLVAALEQVFHHGFKsarifhKNVFIWDFIEKVVAYFettdqild 1170 human
KQK77883     1078 QIQEGIGEAVNNIVKHFHKpekergsLTILLCGENGLVAALEQVFHHGFKsarifhKNVFIWDFIEKAVAYFetsdqigd 1157 blue-fronted ...
XP_007896796 1123 QIQEAIGESINNIVKHFHKpekergsLTVLLCGENGLVSALEHVFHHSFKsarlfqKNVFIWDFIEKAVLYFetteedee 1202 elephant shark
Q6NXD8       1128 QIQESIGEAVNNIIKHFHKpekergsLTVLLCGEGGLVWALEQFFHHGFRsarifqKNVFVWDFFERIVAFMenrdqtgd 1207 zebrafish
OCT86073      994 QIQEGIGEALNNIIKHFYKpekergsLTVLLCGESGLVVALEQLFHHGFKsarifqKSVFIWDFIEKAVAYFettdqigd 1073 African clawe...

Q6ZUT9       1171 neddvliqkssckTFCHYVNAINTaprniGKDGKFQILVCLGTRDRlLPQWIPLLAECPAItrMYEESALLRDRMTVNSL 1250 human
KQK77883     1158 xeealllqrssckTFCHYVNAINTaprniGKDGKFQILVCLGTRDHlLSQWIPLLAECPPItrMYEENALLRDRMTVNSL 1237 blue-fronted ...
XP_007896796 1203 lredllqlkaswrTFCQYVNAINSaprniGKDGKLQLLLCLGARDHlLAQWFPLLSECPVTsrMYEEGALLRDHMMVNSV 1282 elephant shark
Q6NXD8       1208 lqespeplslnseSLCRYVNAINNmprniGKDGKFQLLVCLGARDRlLPQWLPLLAESPVItrMYEENALLRDKLTVSSL 1287 zebrafish
OCT86073     1074 eeedhlisgssckTFCHYVNTIIAaprniGKDGKFQLLFCLGARDHlLALWIPLLAECPAItqMYEENALLRDPMTVNSL 1153 African clawe...

Q6ZUT9       1251 IRILQTIQDFTIVLEGSLI 1269 human
KQK77883     1238 IRVLQTXQDFNIILEGSLI 1256 blue-fronted amazon
XP_007896796 1283 IRVLQTLQEFNITLEASLV 1301 elephant shark
Q6NXD8       1288 LGVLETLHDFPITLETSLT 1306 zebrafish
OCT86073     1154 VRVLQTLQDFNIVLEGSLI 1172 African clawed frog
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