Conserved Protein Domain Family
RUN2_DENND5A
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cd17692: RUN2_DENND5A 
RUN2 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins
DENND5A, also called Rab6-interacting protein 1 (Rab6IP1), is present predominantly in developing neuronal tissue, and functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the second RUN domain of DENND5A.
Links
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Statistics
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PSSM-Id: 439054
Aligned: 6 rows
Threshold Bit Score: 371.179
Created: 14-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6IQ26       1107 QIQESIGEAVNGIVKHFHKpekergsLTLLLCGECGLVSALEQAFQHGFKsprlfKNVFIWDFLEKAQTYYetleknevv 1186 human
XP_007886044 1164 QIQESVGEAINGIVKHFHKpekergsLTLLLCGENGLVTALEQVFHHGFKsprlfKNVFIWDFLEKTYAHFesleqtevt 1243 elephant shark
XP_005989738 1107 QIQESVGEAINGIVKHFHKpekergsLTLLLCGETGLVSALDQVFQHGFKsprlfKSVFIWDFLEKAYTYYgsldhsdlt 1186 coelacanth
NP_001121468 1105 QIQEAIGEAVNGIVKHFHKpekergsLTLLLCGENGLVSALEQVFQHGIRsprlfKSIFIWDFLEKAQAYYeslevnelv 1184 western clawe...
KFQ94246     1049 QIQEAIGEAVNGIVKHFHKpekergsLTLLLCGESGLVSALEQVFQHGFKsprlfKNVFIWDFLEKAQTYYetleqnemv 1128 crested ibis
KPP78941     1206 QIQEAVGEAINGIVKHFHKpekerssLSLLLCGEYGLVWALEQVFLHGFRtprlfKNVFIWDFLERAQAHFespeqrele 1285 Asian bonytongue

Q6IQ26       1187 peenwhtrarNFCRFVTAINNtprniGKDGKFQMLVCLGARDHlLHHWIALLADCPITahMYEDVALIKDHTLVNSLIRV 1266 human
XP_007886044 1244 peenwqtrarNFCKFVSAINSaprniGKDGKFLLLVCLGSRDHlLHHWIALLADCPITaqMYEDMALIKDHTLVNSLIRV 1323 elephant shark
XP_005989738 1187 qgenwqtrarTFCQFVNAINStprniGKDGKFQLLVCLGARDHlLHHWIALLADCPVTaqMYEDTALIKDHTLVNSLIRV 1266 coelacanth
NP_001121468 1185 peedwqkrarNFSRFINAINNnprniGKDGKFQMFVCLGARDHhLHHWIALLADCPIIaqMYEETALIKDHTLVNSLIRV 1264 western clawe...
KFQ94246     1129 peenwqtrarNFCRFITAINNtprniGKDGKFQMLVCLGARDHlLHHWIALLADCPITaqMYEDTALIKDHTLVNSLIRV 1208 crested ibis
KPP78941     1286 qdenwhtrahDFCRFMRAVNStprniGKDGKFQMLVCLGARDHlLHHWIALLSECPITvqMYEDTAMIKDRVLVNSLIRV 1365 Asian bonytongue

Q6IQ26       1267 LQTLQEFNITLETSLV 1282 human
XP_007886044 1324 LQTLQEFNITLEASLV 1339 elephant shark
XP_005989738 1267 LQTLQEFNITLETSIV 1282 coelacanth
NP_001121468 1265 LQTLQEFNITLESSLI 1280 western clawed frog
KFQ94246     1209 LQTLQEFNITLEASLV 1224 crested ibis
KPP78941     1366 LQTLQDFNITLEASLT 1381 Asian bonytongue
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