Conserved Protein Domain Family
RUN1_DENND5B
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cd17691: RUN1_DENND5B 
RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins
DENND5B, also called Rab6-interacting protein 1 (Rab6IP1)-like protein, functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5B.
Links
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Statistics
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PSSM-Id: 439053
Aligned: 4 rows
Threshold Bit Score: 459.135
Created: 27-Jun-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Rab6-interacting protein 1 (3CWZ) in complex with Ras-related protein Rab-6a.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #   #  #   #  #                                                
Q6ZUT9        727 VIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL 806  human
KQK77883      714 VIAQTNWKFVEGLLKECRVKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL 793  blue-fronted ...
Q6NXD8        764 VIAQTNWKFVEGLLKECKMKTKRMLVEKMGREAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL 843  zebrafish
XP_007896796  759 VIAQTNWKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL 838  elephant shark

Feature 1                                                                                         
Q6ZUT9        807 IQFQDREEKqehlAESPVALGPERRKSDsgvmLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQL 886  human
KQK77883      794 LQYQEREEKqehsAESPVAIGTERRKSDtgitLPTLRVSLIQDMRHVQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQL 873  blue-fronted ...
Q6NXD8        844 LHYQAREEKneqqLESPVSNGQERRKTEssvgLPGLRVSVIQDMRHIQNMAEIKTDVGRARAWIRLSLEKKLLSQHLKQL 923  zebrafish
XP_007896796  839 LHFQESEEKregvIESPGGNGLERRRSEtglnLPCLRVSLIQDMRHAQNMSEIKTDVGRARAWIRLSLEKKVLSQHLKQL 918  elephant shark

Feature 1                             #   #  ## #   ##          
Q6ZUT9        887 LSNqpLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFT 932  human
KQK77883      874 LSNqaLARKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFT 919  blue-fronted amazon
Q6NXD8        924 LSNqaLTKKLYKRYAFLRCEEEKEQFLFHLLSLNAVDYFCFTSVFT 969  zebrafish
XP_007896796  919 MFNhsLIKKLYKRYAFLRCEEEKEQFLYHLLSLNAVDYFCFTSVFT 964  elephant shark

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