3CWZ


Conserved Protein Domain Family
RUN1_DENND5A
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cd17690: RUN1_DENND5A 
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RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins
DENND5A, also called Rab6-interacting protein 1 (Rab6IP1), is present predominantly in developing neuronal tissue, and functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5A.
Links
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Statistics
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PSSM-Id: 439052
Aligned: 7 rows
Threshold Bit Score: 433.281
Created: 27-Jun-2017
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptide
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:3CWZ; Mus musculus Rab6-interacting protein 1 in complex with Ras-related protein Rab-6a, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #   #  #   #  #                                                
3CWZ_B         36 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEvnITGVEENTLIASLCDLLERIWSHGLQVKQ--------- 106  house mouse
XP_015141957  743 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEvnITGVEENTLIASLCDLLERIWSHGLQIKQdrsctafvl 822  chicken
XP_007886044  798 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEinITGVEENTLIASLCDLLERIWSHGLQVKQ--------- 868  elephant shark
KPP78941      841 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEgsITGVEENTLIASLCDLLERIWSHGLQVKQ--------- 911  Asian bonytongue
XP_005989740  741 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEvnITGVEENTLIASLCDLLERIWSHGLQVKQ--------- 811  coelacanth
NP_001121468  741 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEvsITGVEENALIASLCDLLERIWSHGLQVKQ--------- 811  western clawe...
Q6IQ26        742 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEvnITGVEENTLIASLCDLLERIWSHGLQVKQ--------- 812  human

Feature 1                                                                                         
3CWZ_B        107 --------------------------GKSALWSHLLHYQENRQRKltsgs-lstsGILLDSERRKSDasAVMSPLRISLI 159  house mouse
XP_015141957  823 edrasvysastqiwafqttrrptlhkGKSALWSHLLHYLENRQRKttsgs-fstsGILLDSERRKSDtsPGMSPLRISLV 901  chicken
XP_007886044  869 --------------------------GKSALWSHLLHYQETKEKKdaisggtsssGTIHDQERRKSDvsLAMPPLKISVT 922  elephant shark
KPP78941      912 --------------------------GKSALWSHLLHYQESKEKKdtpag-lsppGLIHDSERRKSDagLALPPLKVSLI 964  Asian bonytongue
XP_005989740  812 --------------------------GKSALWSHLFHYQEAKEKKeitsgglntsGIIQDTERRKSDtsSAMMPLKVSLI 865  coelacanth
NP_001121468  812 --------------------------GKSALWSHLLHYQDSRRRAtwgs--lggtDLVLDCERRKSDpfLVMYPLKISLV 863  western clawe...
Q6IQ26        813 --------------------------GKSALWSHLLHYQDNRQRKltsgs-lstsGILLDSERRKSDasSLMPPLRISLI 865  human

Feature 1                                                                    #   #  ## #   ##     
3CWZ_B        160 QDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDhELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 239  house mouse
XP_015141957  902 QDMRHIQNISEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDhELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 981  chicken
XP_007886044  923 QDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDqELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 1002 elephant shark
KPP78941      965 EDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDeELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 1044 Asian bonytongue
XP_005989740  866 QDMRHIQNISEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDqDLTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 945  coelacanth
NP_001121468  864 QDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLLDhDLSKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 943  western clawe...
Q6IQ26        866 QDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDhELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCF 945  human

Feature 1              
3CWZ_B        240 TNVFT 244  house mouse
XP_015141957  982 TNVFT 986  chicken
XP_007886044 1003 TNVFT 1007 elephant shark
KPP78941     1045 TSVFT 1049 Asian bonytongue
XP_005989740  946 TNVFT 950  coelacanth
NP_001121468  944 TNVFT 948  western clawed frog
Q6IQ26        946 TNVFT 950  human

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