Conserved Protein Domain Family
RUN_SGSM3
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cd17688: RUN_SGSM3 
RUN domain found in small G protein signaling modulator 3 (SGSM3) and similar proteins
SGSM3, also called RUN and TBC1 domain-containing protein 3 (RUTBC3), or Merlin-Associated Protein (MAP), or Rab-GTPase-activating protein-like protein (RabGAPLP), may play a cooperative role in NF2-mediated growth suppression of cells. This model contains the RUN domain of SGSM3.
Links
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Statistics
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PSSM-Id: 439050
Aligned: 18 rows
Threshold Bit Score: 367.45
Created: 8-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q96HU1       514 DEHCWVGELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVTEgvtDLVRGTLCPALKALFEHGLKKps-llGGACHPWLFI 592 human
Q94222       558 DEHCWVGEVNGLRGWFPAKFVEVVDERGKSYTIYGDEAVSPeitEYIRGRLANSFRQIMDHGIREnalytSMAYHPWSFI 637 Caenorhabditis ...
Q17FM5       566 DEHCWVGELNGLRGWFPAKFVELLDERSKQYSCAGDDAISEtvtDLVRGTLAPTIKQVLEHGMKRps-flGGPCHPWLFI 644 yellow fever mo...
ELU16805     548 DEHCWIGELNGLRGWFPAKFVELLDERSKHYTSAGDDSISEtvtDLVRGVLCPALKSVFEHGLKKss-llGGPGHPWLFI 626 Capitella teleta
GAA48514     568 DEHCWVGELDGVRGWFPANFVELLDERGKNYSSAGDDAVNQniaSLVRGGLCTALSAVFTHGLRRprllgESGCHPWHFI 647 Clonorchis sine...
EFX88003     574 DEDCWIGELNGLRGWFPAKFVQLLDERSKQYSSAGDDSINEniaHLVRGTLAPTIKQVLEHGMKKas-ilGTTCHPWLFI 652 common water flea
XP_002110079 508 DDHCWVGELNGLKGWFPAKFVELLDERSKEYNAAGDDKITDvivPLVRGRLCDALLAVFQHGITKps-vlGAKCHPWAFI 586 Trichoplax adha...
XP_006821156 487 DEHCWVGELNGLRGWFPAKFVELLDERSKQYTTAGDDAVSEtitDLVRGVLAPALKALFEHGLRRpn-ilGGSGHPWLYI 565 Saccoglossus ko...
KPM08727     435 DEHCWIGEFNGKIGWFPAKFVESLDERCQDYCIAGDDRVVPfinVLVRGRLCSALKAILTYDLKQs---yFFNLHPWSII 511 Sarcoptes scabiei
XP_018670908 191 DEHCWVGELNGLQGWFPAKFVELLDERSKTYSKAGDGSVNKtiiDLVRGVFCPALAAIFEHGLRRpv-llGSACHPWQFI 269 vase tunicate

Q96HU1       593 EEAagreverdfasv------------------ysrlvlcktfrLDEDGKVLTPEELLYRAVQSVNVTHDavhaqMDVKL 654 human
Q94222       638 EDIayysveknfnsv------------------ysrltlcntfnLDEDGKILTPEELLFRSVQLINDSHNavsahSDVKL 699 Caenorhabditis ...
Q17FM5       645 EEAatrevekdfesv------------------ysrlvlcktyrLDEDGKVLTPEELLYRCVQAVNQSHDaahaqMDVKL 706 yellow fever mo...
ELU16805     627 EEAatrevekdfesv------------------ysrlvlcktyrLDEDGKVLTPEEILYRTVQSVNFSHDmahaqMDVKL 688 Capitella teleta
GAA48514     648 EEAaakeverdfasv------------------ysrlvlcktfrLDEEGKVLSPEEVLYRAIHSINMSHDlaqahMDVKF 709 Clonorchis sine...
EFX88003     653 EEAaskevekdfasv------------------ysrlilcktfrLDEDGKVLTPEELLYRCVQAVNISHDvvhaqMDVKL 714 common water flea
XP_002110079 587 EEAsikeierdyhsv------------------fsrlvlcktykLDEDGRVLTPEEILYRAVHSVNITHDqlhasMDMKF 648 Trichoplax adha...
XP_006821156 566 EEGseiialcclekcflslgvtnldketlhldvfgvfhwivralLDEDGKVLTPEEILYRSVQAINLSHDaahtqMDVKF 645 Saccoglossus ko...
KPM08727     512 EKIsnntthselksa------------------ysrlvltktfnLDQFNQLLSPNDLLYRSIALVNATHQnc--pMDIKL 571 Sarcoptes scabiei
XP_018670908 270 EEAathevekdfdsv------------------fsrlvlcktfrLDDEGKVLAPEELLYKCIQAVNMSHNnahaqMDVKL 331 vase tunicate

Q96HU1       655 RSLICVGLNEQvLHLWLEVLCSSlp---tVEKWYQPWSFLRspGWVQIKCELRVLCCFAFSLSqDWELPAKREAQQ 727 human
Q94222       700 RSLLVVGVNEQcIHLWFDLLCSAtqhehiRNKYYHSWAFIRspAWRQIKCDLRLLSQFSFNLSmSFEIEGIDKKKR 775 Caenorhabditis elegans
Q17FM5       707 RSLICLGLNEQvLHLWMEVLCSCse---iVHKWYQPWSFIYspGWVQIKCELRLLSQFAFNLNpDWELPAKREATQ 779 yellow fever mosquito
ELU16805     689 RSLLCCGLNEQvLHLWLETLCSCve---vVEKWYHPWSFMRspGWVQIKCELRLLSQFSFNLSqDWELPLKQDLSR 761 Capitella teleta
GAA48514     710 RSLVCYGLNEQlLHMWMETLCSSvk---vVEKWYYPWSYLRspGWVQIKCELRVLSQFAFHLSpIYELATNRLDTA 782 Clonorchis sinensis
EFX88003     715 RSLICMGLNEQvLHLWLEVLGSSis---tIQKWYYPGSFLAspGWVQVKCDLRVLTQFPFNLNlEWELPVSKKSVN 787 common water flea
XP_002110079 649 RSLICIGLNEQvLHLWLEILCSCee---vVAKWYEAASFLRspGWIQIKCELRVLSNFSFNLSaDYEVSKDTNVPM 721 Trichoplax adhaerens
XP_006821156 646 RSLICAGLNEQvLHLWLESLCASeq---iVEKWYYPWSFLRspGWVQIKCELRVLSKFSFNLTlNWELPKKEISAP 718 Saccoglossus kowale...
KPM08727     572 RSLICLGLNQNcLHDWFESICTGnq--siIEKSYGPNSFLRtpAWKLIKAELKLLIQFSFYLSlNMELELMRTKSS 645 Sarcoptes scabiei
XP_018670908 332 RSLICYGLNEQvLHLWLEALCSStp---vVRKWYHPWSFLLspGWVQIKCELRVLSKFTFYLPpDHELPKTKASRE 404 vase tunicate
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