4GIW,6IF2


Conserved Protein Domain Family
RUN_RUSC
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cd17685: RUN_RUSC 
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RUN domain found in RUN and SH3 domain-containing proteins, RUSC1, RUSC2 and similar proteins
RUSC1, also called new molecule containing SH3 at the carboxy-terminus (NESCA), may acts as a signaling adapter that translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. RUSC2, also called iporin, or interacting protein of Rab1, is a novel interacting molecule for the active GTP-bound conformation of Rab1. It may function as a link between the targeting of endoplasmic reticulum derived vesicles, triggered by the Rab1 GTPase and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions. This model contains the RUN domain of RUSC1 and RUSC2.
Links
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Statistics
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PSSM-Id: 439047
Aligned: 34 rows
Threshold Bit Score: 148.973
Created: 8-Mar-2016
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:6IF2: Human RUSC2 binds Rab35, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #   #  #    #                                                          
4GIW_A       7 QKKGLLIAVSVSVDKIISHFGAARnlvqkaqlgds--------------------------------------------r 42   human
6IF2_A      16 QKKGLVKAVNIAVDLIVAHFGTSRdpgvkaklgns--------------------------------------------s 51   human
NP_492018  334 VRRRIHPPVWAQTAQSKTVLCDCAstptdtnfsfapttsttrhqlrakelsi---------vglpiyaakrtlvenvveg 404  Caenorhabditis e...
KFD66174  1012 QKHDMVCKFLLSCDRLRGSLTPDAtlfek--------------------------------------------------- 1040 pig whipworm
CDS28078   833 RYHAMVMDVIRAVQETIAYFCQSTissgtpegsnttgsslshsak-----------------------nnsnyrcyssla 889  Hymenolepis micr...
CEF64467   404 SKLRLHPHQWSKCFKNCNIICECKdinttseyildenminkekklmasthkmklhaheisiiglpiydikrklvenvveg 483  Strongyloides ratti
KIH53477    45 LQIGLIPLHPDMCYVIVHQIDRKPssgsqqirarelsvvglpiys-----------------------tkrtiveavvda 101  Ancylostoma duod...
KOF77242  1257 KKSAMLAEVSKAAEALVDHFSKSKdpfdklrlgss--------------------------------------------v 1292 Octopus bimaculo...
GAU94010   613 QKQELVTLVKAAAMGLVGYRQIRRehldn--------------------------------------------------- 641  Ramazzottius var...
OQV24467   794 QKQELVTLVKAAAMGLVGFRQIQKdhsdn--------------------------------------------------- 822  Hypsibius dujardini

Feature 1                                                                                      
4GIW_A      43 lspdvghlvLTTLCPALHALVADGLKpfrkdli-tgqrrsSPWSVVEASvkpgs-----strsLGTLYSQVSRLaplsss 116  human
6IF2_A      52 vspnvghlvLKYLCPAVRAVLEDGLKafvldvi-igqrknMPWSVVEAStqlgp-----stkvLHGLYNKVSQFpeltsh 125  human
NP_492018  405 vaaisrgdgSDLLVIAMRCLIEDGLQen-----------vSAWTMIQTVtskgp-----atkdVHSIVKQLEECsk--td 466  Caenorhabditis e...
KFD66174  1041 -----lqllHRFVINSIVEMIEDGLVva-----------nSVWSVIVSAtklgp-----atrsVCDLVNALESRna--yk 1097 pig whipworm
CDS28078   890 alggsgrssLVTVVNPLMILISDGLLppqtraifaskpksRIWTLVEDScrpsaylgkiehhiLNEAVNQVKAItgaise 969  Hymenolepis micr...
CEF64467   484 vaeivrnnsKELLCKAIIDLLNDGIEng-----------nDVWRIITKLtasgr-----atnkIYDVMIELNNSpr--si 545  Strongyloides ratti
KIH53477   102 vaaiargeaPNALFTALAALVSDGLKqd-----------vSSWSMIRTVtapgp-----atkdVYSIVNKLDSSek--sd 163  Ancylostoma duod...
KOF77242  1293 etpeigdlvLSRLCPAVAQVINNGLKsyesglhvfgrvhiTVWRVAEASaepgp-----straICDIVKELRNRpnlssn 1367 Octopus bimaculo...
GAU94010   642 ----lsnviEEHFTTALHNLLEDGLKeg-----------yTVWSMVKRCspt---------lyRQHLCSMIDSNsqlvtd 697  Ramazzottius var...
OQV24467   823 ----lshviEQQLTSALHALMEDGLRag-----------cSVWSTVVKQcsp--------tlyRRHLATMIEANdkltsd 879  Hypsibius dujardini

Feature 1                       #                                        #  ## ##   ##    
4GIW_A     117 RSRFHAFILGLLNTKqLELWFSSLQEDAGLLSL---XYXPTGFFSlarg--gcpsLSTELLLLLQPLs-VLTFHL 185  human
6IF2_A     126 TMRFNAFILGLLNIRsLEFWFNHLYNHEDIIQT---HYQPWGFLSaaht--vcpgLFEELLLLLQPLa-LLPFSL 194  human
NP_492018  467 NVKVEIFFEELIRENsLDCWLCYIVLKEKVLKT---LYSENAFLLsass--eyrtLLWRMVDSLSLLp-VIEARS 535  Caenorhabditis elegans
KFD66174  1098 NLKVDLFFLGLFRLQsLDCWLSYLVLKDNLLRK---CYLKSAFLRgars--vysfLYEKILAKIQSLynAFKFDR 1167 pig whipworm
CDS28078   970 KLRFRAFVCACLNQRaLLLWLNSLVSNDPLLKR---YYCEGAFIRqcrs--alqgLYADLTTHIEQLl-NYPFNF 1038 Hymenolepis microstoma
CEF64467   546 ESKVKDFVCALISLRsLDGWLSYIVLKDNVLTK---LYNNNAFLVkant--ayrsLFWRLIESVEWLs-VIDAKQ 614  Strongyloides ratti
KIH53477   164 NSRVEQFFEELYRENsLDCWLCYVVLKENVLRR---LYTPGSFLLdapt--ayrtLLWRLVDALAIIp-VLEVRE 232  Ancylostoma duodenale
KOF77242  1368 KHRFDAFIFALLNSRlLDFWLGYLRHRDNVICH---FYNTNALLQqqlyisdlgdAYEEMLLSLQPLs-VLPFQL 1438 Octopus bimaculoides
GAU94010   698 HGRFHAFIKELMRLGdLNAWMLQLTHGRNDTSTlrhFYSMNGFLFlans--vtkdLWDDLMDTLVCLs-DMSSRS 769  Ramazzottius varieorn...
OQV24467   880 PERFHAFIQELLRLSdLNAWLLQIVQGNTPAALr-qYYSMDGFLFlans--vtkdLWDDLMDTLSWLs-STSQSH 950  Hypsibius dujardini

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