Conserved Protein Domain Family
RUN_PLEKHM1
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cd17679: RUN_PLEKHM1 
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins
PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.
Links
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Statistics
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PSSM-Id: 439041
Aligned: 40 rows
Threshold Bit Score: 208.599
Created: 8-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9Y4G2         15 IPVIKKKLVGSVKALQKQYVSldtvvt--sedgdANTMCSALEAVFIHGLHakhiraeaggkrkksahqkplPQPVFWPL 92   human
KMQ92742       21 RDSLQKQLNTSVMEMQSAPGVaddgvv--sncdeTMTLCSVLEAIFLHGLKdsllnrvtea--lsgpdfdamPQPSFWGP 96   Lasius niger
KDR14325       19 KESLISQLSSSVKEIQLEMSKthvs------adtTASLCTVLEAIFIHALKdtfmnrvsq---aisadpdqrPEPSCWGP 89   Zootermopsis ...
XP_002158691   28 KKRLKENLLTQIRKLQKSHVGnenivd--rndedAASLCMALEAIFLHEINlnhkisfes---fesiknedtLSISFWEL 102  Hydra vulgaris
XP_003740629   21 RKTLARYTVATVKDVQMEALRnperki--tqgdvANRFCEVIEAIFLHGSKgrltkmms-----dvfggsrlPKPDFWDL 93   western preda...
XP_008180219   20 KASIIHYFEERLNEFHSEFSDtdvkvt--ssnyvADRLLAVLEVLFLHGLKetfisqlst---vigndvdktMDINFWHC 94   pea aphid
XP_018900610   19 KKSIIAQVSISIKEIQLEYAEsdtsl---vasnvTDGLCTALEAIFIHGMKetffnkmsf---alsndldslPQPNFWPA 92   Bemisia tabaci
XP_017782822   20 KSSITTQLSETVKDIQLCSIEegds------leaKNNLCSVIEAIFLHGLKdsiahrfrk----aisdvdqrPEPNFWSP 89   Nicrophorus v...
XP_019848996   21 RRRLCNELSSTIKVIQEDHVRtklvk---gvhfgAIQLCEILEAIFLHELKdkrgvlwrek--vssepmadlPEPSFWSC 95   Amphimedon qu...
KPI93483       21 KESLVNNLSDCVKDIQYNSQFddnfhsvlgssdsTNTLCMALEAVFLHGLKdtflrkakn---vissdpdyrPQSSFWPL 97   Papilio xuthus

Q9Y4G2         93 LKAVtHKHIISELEHLTFVnTDVGRCRAWLRLALNDGlMECYLKLLLQEqarLHEYYQPTALLRDaEEGEFLLSFLQGLt 172  human
KMQ92742       97 LLVFsHRQIIDQIQALSQVtTEVGYCRAWIRLALNEGlLASYFCSIRRDnsaLKPYYNRSAYIRDvDLVEVAQRLIESLd 176  Lasius niger
KDR14325       90 LLIFsHREIIDQINALNLVtTDVGRCRAWLRLALNDGlLSSYFVSMRRDgsaLKPYYRRSAFLRDtEMLDVAQRLVEGIe 169  Zootermopsis ...
XP_002158691  103 LKKVtHKDVLTQLQQLVVK-TDVGLCRAWLRLALNDGiITSYLNAIIAEnkfLSTFYNSNAFLLDeELPNILKDILQGIl 181  Hydra vulgaris
XP_003740629   94 VMLYtHRDDLQTLSSLDQItTDVGRCRAWVRLVITDGtLSSFVECISQDvkaLPSFYRSSAFLRDpELVAIVIRLLSSLl 173  western preda...
XP_008180219   95 LLVLsPSGVVDQINSLRHVtTDVGKCRAWIRCTLNDCvFRSYLMSAVKYrryIIKFYNKTAIIRDhQCFEKIIGLLESId 174  pea aphid
XP_018900610   93 LLVYsHREVIDQINKLSQVkTDIGRCRAWLRIALNETlTSSYLATMKKDsrtLRHYYKTSAFLRDpECLSIAITMIEGIe 172  Bemisia tabaci
XP_017782822   90 LLIIlHRESIEQIQQLKQItTDIGHCRAWIRLSLNEAlLSSYLMTIRQNpsaLKSYYNTFAYIRDiDELEVAQKYIEGIe 169  Nicrophorus v...
XP_019848996   96 ISPLvSDEIKTQLLALRNSeSDIKKCRSWVRLMLVKGlLFSFLSDIQKHpglLGPHYGPEAVLKDtERSEIIQTLLRGLe 175  Amphimedon qu...
KPI93483       98 VLILsHRQNIDQISSLPQInTEIGQCRAWLRIALNEClLSSYMATLLKNisaVKPFYNRAAFVCDaEILEVAQKLVQGLe 177  Papilio xuthus

Q9Y4G2        173 -SLSFELSYKSAILNEW 188  human
KMQ92742      177 -YVRFELACNSSLLNFW 192  Lasius niger
KDR14325      170 -SCPFSLACNSSLLNVW 185  Zootermopsis nevadensis
XP_002158691  182 -QFEFRLNYNSSKLDTW 197  Hydra vulgaris
XP_003740629  174 sHVKVSLPLNVASLNVW 190  western predatory mite
XP_008180219  175 -QYHFELTLNSSLLNTW 190  pea aphid
XP_018900610  173 -ACRFELAYNSSLLNAW 188  Bemisia tabaci
XP_017782822  170 -SIDLELPYNNSLLNSW 185  Nicrophorus vespilloides
XP_019848996  176 -VFEFEYDFSSTRLTSW 191  Amphimedon queenslandica
KPI93483      178 sCVQFNLPTNSSLLNQW 194  Papilio xuthus
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