Conserved Protein Domain Family
RUN2_DENND5
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cd17678: RUN2_DENND5 
RUN2 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins
DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the second RUN domain of DENND5.
Links
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Statistics
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PSSM-Id: 439040
Aligned: 27 rows
Threshold Bit Score: 195.507
Created: 8-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6IQ26       1107 QIQESIGEAVNGIVKHFHKpeke------rgsLTLLLCGECGLVSALEQAFQHGFKspr---------------lfKNVF 1165 human
XP_009860951  932 ELQERMGRHVNAIVKYQHHpihdvrtnhtpppASFTKLLVDGLVATINKVFTHGIKsgg--------------lfqKKIF 997  vase tunicate
CCD81326     1147 IIHERVANAVNCLLKFFCKtnntn---tmttsLTSLWCGEHGLVPALHLVFTYGFRssr--------------ifqRKIY 1209 Schistosoma m...
CDS27730     1088 TVLDRLANAVNRLAKHFACagqae---sfmslSALLCGKEHGLAPALEAVFTHGIRssgv-------------fnrRRLY 1151 Hymenolepis m...
ERG78780      498 EIQQQLGEAVNAIVKHFYGgvea-----rselTQLLCAPERGLVSVMVSVFLYGRQdsiws-----------arffKQHY 561  pig roundworm
CEF59483     1348 EVQHLLRTVVNSITKYFCSengd-----nvskLTHLLCGELGFVFCFEQVFLIGRRdsvfy-----------nrffKQLY 1411 Strongyloides...
XP_003745377 1161 DVQQWLANAINKMVKHHNGpqse------rvnLTILMCGEYGLLFALEQVFYHGYRgkivgtpplsvpftpssrffGQLT 1234 western preda...
KRY75886      345 QIQHQLGDAVNNIVKYFYRpdae------rnvLTHLLCGEKGLVSCLNEAFLLGYRgapr-------------lfrQSYF 405  Trichinella p...
NP_495437    1305 EVEHLLGEAVNALVKYFCSerkv------kseLAHLLCGQKGLVLAIEQAFQLGRQesll-------------kyfRNTC 1365 Caenorhabditi...
KFD64116     1151 LVQQQIGDAVNRIVKHFYPcdne------htsLTHLLCGEKGLVSCLNDAFLVGLRstraha---------sqfslRQMY 1215 pig whipworm

Q6IQ26       1166 IWDFLEKAQTYYetleknevvp---------------------------------------------------------- 1187 human
XP_009860951  998 AWDVLVAGCNLYqsnpqqqqpsnpqhtrqqhtkvggdwflgsrn------------------------------------ 1041 vase tunicate
CCD81326     1210 VWDYFVSTSDNLntsknqpidilinn------------------------------------------------------ 1235 Schistosoma m...
CDS27730     1152 AWDFFERFVEHHtriasnenqqssrhiesdstsmniggfdvsfatspyfartlprqstsgsglrnldssgrrtpllsrat 1231 Hymenolepis m...
ERG78780      562 PWDYIEKVCAWFfelirmddakk--------------------------------------------------------- 584  pig roundworm
CEF59483     1412 AWDFIERVCSWFydllksgeskk--------------------------------------------------------- 1434 Strongyloides...
XP_003745377 1235 LWDFMLKVKAFFktflgeneatle-------------------------------------------------------- 1258 western preda...
KRY75886      406 AWDFVEKFASCCaefskkksfrqdkydawfl------------------------------------------------- 436  Trichinella p...
NP_495437    1366 PWDYIERVCSWFfelcrkkevdk--------------------------------------------------------- 1388 Caenorhabditi...
KFD64116     1216 PWDFIESFACCSaekgkrrpidckkyecwld------------------------------------------------- 1246 pig whipworm

Q6IQ26       1188 -----------------------------------------eenwhtrarNFCRFVTAINNtpr-niGKDGKFQMLVCLG 1225 human
XP_009860951 1042 -------------------ngrhhnrddettivqsqesvermkvsmdlmcSLCNRVSNIQHt----lGKDEMFVLIICIS 1098 vase tunicate
CCD81326     1236 ------------------------------------rlasmsnsaqqsalQFTMYVQNITNnsi-tfGKEGKFQRFICHA 1278 Schistosoma m...
CDS27730     1232 prlslkssalppiqpptasssgwqsqpcspgvalqrrqyysstrsifaleNFISTFQQVNRsgs-qiGKLGKFQRMVCIG 1310 Hymenolepis m...
ERG78780      585 ----------------------------------------ltreqrslisHACRLVRKISSnt--alGKDGKFQLFILVT 622  pig roundworm
CEF59483     1435 ----------------------------------------ltkdriallaHTVRLFNKISSnn--viGKEGKFSVFILFA 1472 Strongyloides...
XP_003745377 1259 --------------------------------------pkrrdellnvmsGFIKLVDKIEGaasytiGKDQRFQAFMCIT 1300 western preda...
KRY75886      437 --------------------------------svsknqaavagddgflliYLRRLVEKINGnt--gvGKEGKFKIFVLVA 482  Trichinella p...
NP_495437    1389 ----------------------------------------lpkeqktmihHALRLYRKIDAkt--slGKDGKFHVFVLLS 1426 Caenorhabditi...
KFD64116     1247 --------------------------------gmsknektqgvddtpfimNYCKQVVEKVNrnp-tvGKDGKFKTFVLLA 1293 pig whipworm

Q6IQ26       1226 ARDHlLHHWIALLADCPITa----hMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLV 1282 human
XP_009860951 1099 LQQHlLPVCLPKIASLAQAs----nYFDESAFLSDNSAVSFLAQVLSMLNEYKLNVDDSLF 1155 vase tunicate
CCD81326     1279 LRDHlLSDWLSILAISPITy----nMYEPRSFLLSHDLRKIIQDLLTSLDEFHLTFEPALL 1335 Schistosoma mansoni
CDS27730     1311 CRDHtIASWFPVLATSAPNlvkqmyDTRIPNFLIDPDLRDSVQTLLTTLNDFKFKLDPALL 1371 Hymenolepis microstoma
ERG78780      623 VRDHvLSGLLPLMAWTPITa----qLYDEPSFLRTPHYLTYLAKLLSSLNEFQFNLENSLT 679  pig roundworm
CEF59483     1473 LRDHiLPGLLVIMAWTPVTp----qMYDDNSFLRNKTLLSSITQLVESLKQFQFNLEKSLV 1529 Strongyloides ratti
XP_003745377 1301 IRDHfLHRMLVHVASTPVTs----qLYQENSFFRDSSLLSVLVQTLESLNQIDYSSLEKCL 1357 western predatory mite
KRY75886      483 LRDHlLPSVISLMARSSITt----sMYDETSFFRIPQHRMFLTHLLMSLNEFQFELDQSLI 539  Trichinella pseudospiralis
NP_495437    1427 IRDHiLPGLLPLMRYSPVTa----dMYNEPSFLRTPAHMTYLAKLMYSLSEFNITIDPSLT 1483 Caenorhabditis elegans
KFD64116     1294 LRSHlLSSVVSTMACSPVAa----kMYDEISFFRIHDCALFLTDLLLSLDDFNFDLDEALI 1350 pig whipworm
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