3CWZ


Conserved Protein Domain Family
RUN1_DENND5
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cd17677: RUN1_DENND5 
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RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins
DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the first RUN domain of DENND5.
Links
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Statistics
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PSSM-Id: 439039
Aligned: 12 rows
Threshold Bit Score: 286.987
Created: 8-Mar-2016
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptide
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:3CWZ; Mus musculus Rab6-interacting protein 1 in complex with Ras-related protein Rab-6a, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #   #  #   #  #                                                
3CWZ_B         36 VIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHge-vnITGVEENTLIASLCDLLERIWSHGLQvk--------- 105  house mouse
KOF62755      666 AMAQRNWQFVETLLKECRTKTKRMLVEKMGQEAVELGHge-vnITGVEENTLIASLCDLLERIWSHGLLtk--------- 735  Octopus bimac...
XP_013380096  742 GMMATNWKFVETLLKEAKGKTKRMLVEKMGQEAVDLGHgdqvtLTGVEENTLIASLCDLLERIWSHGLQtk--------- 812  Lingula anatina
NP_647620     839 LIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLk----GDGIEENTLIASMCDLLEKIWSHGLQnk--------- 905  fruit fly
XP_012561027  787 ATQRTLNVYAEKLLKECKMKTKRLVVLKLGQEAIELGHvg-pnSIGIEENTLIASLCDLLERVWCHGVQlnqldfdkesv 865  Hydra vulgaris
KPM07491      554 MTAPTNWKVVETLLKEVKIKTKRILLAKMGTDEIGTLKns-spQVSQEDNILITALCDLIERIWSHARSfdydent---- 628  Sarcoptes sca...
XP_006818506  693 VMAQTNWKFVEGLLKECRVKTKRMLVEKMGQEAVELGHge-vkLTGVEENTLIASLCDLLERIWSHGLQtk--------- 762  Saccoglossus ...
ELU14295      730 GAAQTNWKFVESLLKECKAKTKRMLVEKMGQEAVELGHge-avITGVEENTLIASLCDLLERIWSHGRHqv--------- 799  Capitella teleta
XP_020606052  813 MGLEPQTGFIEKLLKECRQKTKKILVQKMGQEAVDLGHsd-anVSGVEENTLIASLCDLLERVWSHGLQtr--------- 882  Montastraea f...
CDQ62524      727 AVTQIQRGFVEGLLSECRLKTRRMLMERMGKESVELGQge-asITGLQENTLIHSLCDLLERTWGHGLLlk--------- 796  rainbow trout
KZS20006      752 VIAQGNWKFVEQLLQECKTKTKRLLVGKMGSEAFELGHgq-vsVSGVEDNTLIAGLCDLLERVWAHGLQtk--------- 821  Daphnia magna
Q6ZUT9        727 VIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHge-anITGLEENTLIASLCDLLERIWSHGLQvk--------- 796  human

Feature 1                                                                                         
3CWZ_B        106 ---------qGKSALWSHLLHYQENRQRkltsgslstsgil--------------------------------------- 137  house mouse
KOF62755      736 ---------kGKSAFWSHMLSFLELETIidagkpidpklltpaatagslqvaatqmvtlvpgllqnstnlmnyltppvad 806  Octopus bimac...
XP_013380096  813 ---------qGKSALWSHLLNFQEIEECndnskpidpnfltpdistlaldgdgsr------------------------- 858  Lingula anatina
NP_647620     906 ---------qGKSALWAHLQAYLEMQEArgagdssgteqtppvssspggkmtiataspalawnam--------------- 961  fruit fly
XP_012561027  866 kskfvqrmrqSKSALWSHLLAFYQKECSklaaiygianvecvpgemknlvneanqksfrskspa---------------- 929  Hydra vulgaris
KPM07491      629 ---snsvasaNKCLFWSHLKAYFESSRNeinnnsiqikdminspnqedqnqssswis----------------------- 682  Sarcoptes sca...
XP_006818506  763 ---------qGKSALWSHLLAYQDMRVRkdsspdpnflvpieaqwkqyl------------------------------- 802  Saccoglossus ...
ELU14295      800 ---------qGKSALWSHLLSYQETYHRvlwnlqltphlpval------------------------------------- 833  Capitella teleta
XP_020606052  883 ---------eGKSAVWSHLLTFQLECEEieddpsysqdtnslspqaaiketdk--------------------------- 926  Montastraea f...
CDQ62524      797 ---------qGRSALWSHLLHCQANGEKmeqpspaespv----------------------------------------- 826  rainbow trout
KZS20006      822 ---------qGKSALWSHILHYHDLKTApavskpvkassqapdlsapsydgd---------------------------- 864  Daphnia magna
Q6ZUT9        797 ---------qGKSALWSHLIQFQDREEKqehlaespvalg---------------------------------------- 827  human

Feature 1                                                                                         
3CWZ_B        138 -------------------------------------------------------ldserrksdasavMSPLRISLIQDM 162  house mouse
KOF62755      807 fhagnlwpalsiqdnspynnngevhaamiwfilrkrivnavsaegekekpaapthrrsrskggtelpmLKPLPKSLTFDV 886  Octopus bimac...
XP_013380096  859 -----------------------------------------sgtpeatppgtpkkhkrknsrgpelptLIPLRESVTFDM 897  Lingula anatina
NP_647620     962 --------------------------------rkrmdylstfqtdfdsppspnrsrsrdrnkfvgleqLCPLPESLEFDV 1009 fruit fly
XP_012561027  930 ---------------------------------nedgtyfdqltikeakfegvnkspttslfqsrehqDLLTKVHFLNNL 976  Hydra vulgaris
KPM07491      683 ---------------------------------------lkkridslsqlsldhnssnsraslstsliFKSIPTTLFYDY 723  Sarcoptes sca...
XP_006818506  803 ------------------------------------------------spdspllghrrrgsglpdpvLPPVPTDLTHDI 834  Saccoglossus ...
ELU14295      834 ------------------------------------------------------glprkpsrtpeipiLNPLPSSLLFDL 859  Capitella teleta
XP_020606052  927 --------------------------------------------qsqmgrrctspdisnmlqsiqlsqQQNTISSVLADM 962  Montastraea f...
CDQ62524      827 ---------------------------------------------------------sngldsmrleeGLAPPGSFVQDM 849  rainbow trout
KZS20006      865 ---------------------------------------------gaanrsrssnsidnnragnppnrMKPLPESLIFDM 899  Daphnia magna
Q6ZUT9        828 ---------------------------------------------------------perrksdsgvmLPTLRVSLIQDM 850  human

Feature 1                                                                 #   #  ## #   ##        
3CWZ_B        163 RHIQNIGEIKTDVGKARAWVRLSMEKKlLSRHLKQLLSDheLTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNV 242  house mouse
KOF62755      887 KKVKQMTDIKTDVGFARAFVRLALEKKtLSAHLKELLSDakLLQSLYKRYAFMRCEEEREQFLYHLLSLNAVDYFCFTNT 966  Octopus bimac...
XP_013380096  898 KNILKMKDIKTDVGYARAWVRLALEKKlLSRHLKELLSDtdLLRSSYKRYAFLRCEDEREQFLCHLLSLNAVDYFCFTNT 977  Lingula anatina
NP_647620    1010 KNVLAMADIKTHIGYTRAWVRLSLEKKlLSRHFRTLLSDeaLLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNI 1089 fruit fly
XP_012561027  977 KTIIDMKEIKTDTGYARAWTRLALEKKtLAEELRILLDQkkILEARYKNYAFIRTEDEMEQFLIHLLSLNAVDFYCFTNG 1056 Hydra vulgaris
KPM07491      724 KSIDEMKEIKTDIGKSRAFIRLSIERKlLSKHLRTLLYNqdLLQSLYKRYAFLRCEDEREQFLTHLLTLNAVDLNCFTYT 803  Sarcoptes sca...
XP_006818506  835 RKIQSMKDVKTDVGYARAWIRLALERKlLSKHLKELLSDyeLCKSRYKRYAFLRSDDEKEQFLFYLLSLNAVDYFCFTNS 914  Saccoglossus ...
ELU14295      860 KNVQQMSEIKTEVGYTRAFVRLALEKKlLSKHLKQLLSNpdLLRSLYKSYGFLRCEDEREQFLYHLLSLNAVDYYCYTNA 939  Capitella teleta
XP_020606052  963 SHVQGMAEIKTDVGHARAWIRLALEKKvLSKHLKQVLTNtdLLRERYKDYAFLRTEEEKEQFLYHLLSLNAVDFFCFTNG 1042 Montastraea f...
CDQ62524      850 RFVQTMSEGLSEVGRARAWIHLSLEKKvLSQHLKLLLANqnLIRQLYKPHAFLLCEEEREQFLFHLLSLNTVDYLCFTRT 929  rainbow trout
KZS20006      900 RNVQNMADIKTHLGYARAWVRLCLEKKlLYVHLTTLLSEenLLRTLYKRYAFLRCEDERNLFLTYLLTLNAADYHSFTHT 979  Daphnia magna
Q6ZUT9        851 RHIQNMSEIKTDVGRARAWIRLSLEKKlLSQHLKQLLSNqpLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSV 930  human

Feature 1           
3CWZ_B        243 FT 244  house mouse
KOF62755      967 FT 968  Octopus bimaculoides
XP_013380096  978 FT 979  Lingula anatina
NP_647620    1090 YP 1091 fruit fly
XP_012561027 1057 FS 1058 Hydra vulgaris
KPM07491      804 FT 805  Sarcoptes scabiei
XP_006818506  915 FN 916  Saccoglossus kowalevskii
ELU14295      940 FS 941  Capitella teleta
XP_020606052 1043 FQ 1044 Montastraea faveolata
CDQ62524      930 FI 931  rainbow trout
KZS20006      980 YT 981  Daphnia magna
Q6ZUT9        931 FT 932  human

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