SWIB domain found in BRG1-associated factor 60B (BAF60B) and similar proteins
BAF60B, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (SMARCD2), or 60 kDa BRG-1/Brm-associated factor subunit B, is a component of the BAF complex. It is involved in transcriptional activation and repression of select genes by chromatin remodeling. It plays a role in the ATM-p53 pathway in sensing chromatin opening by facilitating ATM recruitment to the SWI/SNF complex, as well as ATM activation. It also regulates transcriptional networks controlling differentiation of neutrophil granulocytes. Thus, it acts as a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
Comment:The SWIB domain and the MDM2 domain share a common evolutionary origin and thus adopt similar structures, which suggests the SWIB domain may interact with a helical peptide through a cleft on the surface.
Comment:Based on the structural evidence that MDM2 domain binds p53 or other peptides.
Jiyao W et al.(2023). "The conserved domain database in 2023.",