4BT2,1XCR,1XV2


Conserved Protein Domain Family
AldB-like
?
cd17297: AldB-like 
Click on image for an interactive view with Cn3D
proteins similar to alpha-acetolactate dehydrogenase
The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an H(x)H(x)nH motif (x could be any residue, n could be 9 or 10) that coordinates a zinc ion. The proteins are homologous to bacterial alpha-acetolactate decarboxylase (AldB, E.C. 4.1.1.5), which converts acetolactate into acetoin.
Links
?
Statistics
?
PSSM-Id: 341209
Aligned: 478 rows
Threshold Bit Score: 73.6531
Created: 14-Jul-2015
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding siteputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:1XCR: Homo sapiens PDT012 coordinates zinc
  • Structure:4BT2: Brevibacillus brevi acetolactate decarboxylase coordinates zinc
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4BT2_A        22 KNVLFQYSTINALMLGq-FEGDLTLKDLKLrg---------------dMGLGTINd----lDGEMIQMg----------- 70  Brevibacillus b...
1XCR_A        57 KTRIAEVGGVPYLLPLvnQKKVYDLNKIAKeiklp---------gafiLGAGAGPfqtlgfNSEFMPViqtese---hkp 124 human
XP_018393423  70 NTAIVEFPGSTENIPW--NERTRDIKSVLSascq----------dsfiIGSSYATkpqmpyFGHLIMNakyrap----en 133 Cyphomyrmex cos...
AAX27376      53 KGTICDVGSFDYLLPVpkTDRHYDLLDVFKsagit---------vgavIGAGAGPffltgsNSEMVINisseng----kv 119 Schistosoma jap...
NP_001232953  72 DENVFDIGDVTNLLPSlkREKLYNVKDLKQitgsd---------plfiIGACAGPypffgaDSECVENvkmtg-----dr 137 pea aphid
XP_018911044 387 SPSLISCGTVTNFVPKlkLERTFNLKMFPPlagle---------sasfIGTGMYHchesgyLPETTVNasiskg----el 453 Bemisia tabaci
XP_009170222 199 SETLCDIGSFDYLLPVpnKEKRYDLLDAFSlshvg---------sgfiMGAAAGPhfvagiNSELVANlsatdg----kv 265 Opisthorchis vi...
EUB61511      91 KSVVCDVGSMTYLLPVanTSKRYSFGQVIEssgvc---------ggqlLGAGGGPffthgkSCEMAASlqfang----ki 157 Echinococcus gr...
EFN73155      52 NTALLEVGSLSNLFPFprMEKKYDFISFLEtsgrsn-------ddnfiIGASLYPssn-ghMGELIMNasfspldeegmr 123 Florida carpent...
XP_011696803  60 DTAIFDVGGVSNLFPFpqENKIYFFKDMVRtfnrlrrvrstlpndtliIGGGLTKvseeklLGELIINasfder---tav 136 little fire ant

Feature 1                                                                                        
4BT2_A        71 --tKFYQIDSt-------GKLSElpes-----vktpFAVTTHFepk----ektTLTNVqd-ynQLTKMLEEkfe------ 125 Brevibacillus b...
1XCR_A       125 pvnGSYFAHVnpa--dggCLLEKysekch-dfqcalLANLFASegqpgkvievKAKRRtg-plNFVTCMREtlekh--yg 198 human
XP_018393423 134 ftnASRIIFTrtd--ngqRRIETlihpnq--mtyanHGSFFLSegrtgnvirmRARGRrmtnmDIITLMQKilseyt-gr 208 Cyphomyrmex cos...
AAX27376     120 sknSSLLGSYdke--nnkPLITKadnt-----kfalLGQMYMCegksgpvielCVSGRir-dgKLDAMIREalhkkyghl 191 Schistosoma jap...
NP_001232953 138 venGTHVHMTksdd-vpeCFHKSlpdde---mrfsmMANFFTSngfkgevlkiVCEVRkg-plSYSTCIKEalvkh--fg 210 pea aphid
XP_018911044 454 dinKTVGLYMdki--skkHILKSapitl---aefpcLLDLLFSkgekskvlrvHCSKRtg-efSLPSILRNglrth--fp 525 Bemisia tabaci
XP_009170222 266 lqnGSYCGSYdak---nnLPVSTlsets----lfamVGQMFLCegkpgkviqlTVSGRtr-egKFDALLREalaskygal 337 Opisthorchis vi...
EUB61511     158 asnSTLHGVYdeq--tgtPQVINatdn-----nfglVGQLLSSeglpgsvvevDVAGRlk-egSVYVFLREvltaaygkl 229 Echinococcus gr...
EFN73155     124 vknRSYVAFLaqdhtgenVKLDIlndynr--vkcflHGNFFISegkpgrvleiHAKARre-dkELTKVIQHtlqkyyeat 200 Florida carpent...
XP_011696803 137 iknKSRFAFLktleqsknQKCKLiplidntnpkchmYGNFFFNnglreqvlkiQAKNRvs--rDFTVALQRaisrfa-sd 213 little fire ant

Feature 1                                                                                        
4BT2_A       126 nknVFYAVKLTgtfKMVKARTVPkqtrpypq----ltevtkkqSEFEFknvKGTLIGFYtpnyaa-----------alnv 190 Brevibacillus b...
1XCR_A       199 nkpIGMGGTFIiqkGKVKSHIMPaefsscpln--sdeevnkwlHFYEMk-aPLVCLPVFvsrdpg------------fdl 263 human
XP_018393423 209 nttEFFGGVLRmryGQVACNVMCdeypgrilsf-nnfflqqqcIEITLe-sDLIAVGVIfnniplpladq-eqryginly 285 Cyphomyrmex cos...
AAX27376     192 sssVGLGGVIIqekGKSLYHVLPefsqepids---neklrnwiKMFEMe-sPVISVGIVvshdph-----------hlgl 256 Schistosoma jap...
NP_001232953 211 neiIALGGVILienGKVKVHVIKpsltkipik--sekelgnllHFIELs-pPLVGVGCIvshdpg------------lnl 275 pea aphid
XP_018911044 526 dklIGLGGTFLvkqGMATCHVNHlsendqfrevsfeeffkdscTFINMs-aPLVAVGEIisqdpg------------lel 592 Bemisia tabaci
XP_009170222 338 drpVGVGGVVVqetGKCLFHVLPefceepldt---peklkqwlKFFEMe-aPVVAVGTAlshdpq-----------kwki 402 Opisthorchis vi...
EUB61511     230 dkpVALGGVFVltdSKARFHVLPnfppypvdt---parraefiKIFEMd-pPVLGMGTLvshdpy-----------gidl 294 Echinococcus gr...
EFN73155     201 stlVGLGGTFVvhnGLVRHHLMPdigqislencsdesrirnwvKTRILt-tPLVAVGTIvnkssfpvvltnsklqtdlql 279 Florida carpent...
XP_011696803 214 gdlMGLGGTFVvknGKTKHHIIQndwkgpirk---steirkcvQFCEMp-tPVVAFATFlsadryyysk---fppkinfl 286 little fire ant

Feature 1           # #          #                             
4BT2_A       191 pgFHLHFITedktsGGHVLNLQf------dNANLEISPIhEFDVQL 230 Brevibacillus brevis
1XCR_A       264 rlEHTHFFSrh-geGGHYHYDTtpd---ivEYLGYFLPAeFLYRID 305 human
XP_018393423 286 nrSEFHCFSny-gaGGQFISDTtpn---ttEYEGYFNVAkKLIDVK 327 Cyphomyrmex costatus
AAX27376     257 rlEHFHCFNqdhtnCGHCHFDThgp---svSYRAYFALAeHLVRID 299 Schistosoma japonicum
NP_001232953 276 rlQHFHLYTdh-nqGGHYYNDTepe---tiKYTGYFGVSkQFTKID 317 pea aphid
XP_018911044 593 rlEHFHCYSnh-gdGGHFHYDTtpe---svEYLGYFSIAeTLYRID 634 Bemisia tabaci
XP_009170222 403 rlEHFHCFNrdrtkSGHCHFDSdgp---taSYTAYLVPGkRLLRVD 445 Opisthorchis viverrini
EUB61511     295 klEHFHCYNeaktlAGHFYWDTdpe---kaHYRLYLTVAkSLLRID 337 Echinococcus granulosus
EFN73155     280 ttNHFHSFSfeplvGGHYYTNVeyg--nsaEYLGYFCPAkKLYRLD 323 Florida carpenter ant
XP_011696803 287 trWHAHSYSaf--gGGHYHETKqnsednnvEYLGYFSIAtKLYRID 330 little fire ant

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap