Conserved Protein Domain Family
FERM_F1_PLEKHH3
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cd17207: FERM_F1_PLEKHH3 
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in pleckstrin homology domain-containing family H member 3 (PLEKHH3)
PLEKHH3 is an uncharacterized Pleckstrin homology (PH) domain-containing protein that shows high sequence similarity with unconventional myosin-X, an actin-based motor protein that plays a critical role in diverse cellular motile events, such as filopodia formation/extension, phagocytosis, cell migration, and mitotic spindle maintenance, as well as a number of disease states including cancer metastasis and pathogen infection. In addition to two PH domains, PLEKHH3 harbors a MyTH4 domain, and a FERM (Band 4.1, ezrin, radixin, moesin) domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).
Links
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Statistics
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PSSM-Id: 340727
Aligned: 6 rows
Threshold Bit Score: 175.306
Created: 5-Jan-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
key conserved
Feature 1: key conserved lysine K33, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K33/R (Ub numbering) is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), the other 6 lysines are not conserved in this subfamily; may have other functions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            #                                           
Q7Z736       401 RQELLCTVHCP-GAGACAVAIDSHTTAGEVARELVGRLGLarSRNAFALYEQRgaQERALAGGTLVADVLTRFENLAaee 479 human
XP_700015    395 RQEILCTVHYP-GPGCCQIPITSHTTANEVVRKMAERLGLqdSRNTFGLFEQNacWEKAIGGSTIIADVITRFENLSakd 473 zebrafish
XP_014342722 356 RQEMLCTIHYPaGSGSCKIAINSHTTAEEVVMKMVGRLGLenSRNIFALYEQNnqLERAVGKTTIVADILTRFENLAgee 435 coelacanth
XP_010584039 323 RQEMICTVHCP-GAPACSVAISSHTTAEEVARELVSRLGLsqSPNLFALYEQSrrREQPVGSATLLADVLTKFENLAgee 401 bald eagle
XP_007899654 388 RQQVSCTVHCA-GAGTCSIAIGSHTTAGEVVKQLIGRFGLgdSRNIFALFQQCggEEHLIASSAVVADILSRFENLNsne 466 elephant shark
XP_018423286 395 RQALICTIYYP-GSGVCKVPITSHTTAEELVAELMKRLDLssSLNLFALYEQNnqYEQALGKATIIADTLTRFENLTckd 473 Nanorana parkeri

Feature 1                             
Q7Z736       480 agledspdsGWRLCLRLHGPL 500 human
XP_700015    474 p----dsdcQCRLCFKLYCLL 490 zebrafish
XP_014342722 436 k----nsdpQWRLIFKLYCFL 452 coelacanth
XP_010584039 402 r----eqdpPCRLCFKHYGFL 418 bald eagle
XP_007899654 467 e----epekQGKLHFKLYCVL 483 elephant shark
XP_018423286 474 k----gfetRWRLYFKLYCFL 490 Nanorana parkeri

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