Conserved Protein Domain Family
DCX2_DCDC2B
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cd17153: DCX2_DCDC2B 
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B)
DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.
Links
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Statistics
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PSSM-Id: 340673
Aligned: 6 rows
Threshold Bit Score: 152.982
Created: 25-Jun-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
key conserved
Feature 1: key conserved lysine K33, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K33/R (Ub numbering) is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), the other 6 lysines are not conserved in this subfamily; may have other functions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                               #                                         
A2VCK2        128 PSYIHVFRNGDLVSPPFSLKLSQaaSQDWETVLKLLTEKVKLqsGAVCKLCTLEGLPLSAGKELVTGHYYVAVGEDEFKD 207  human
XP_007902508  134 PCIINIFRNGDLLTAPFRLVIPKhvMSDWDTILAMVTEKANLrtGAARRLYTLDGSVIDRGTKLESGQYYVGVGSEKFKH 213  elephant shark
EMP28420      895 QNGCPVFRNGDLLSPPFRLLLSKstLQEWDAILGLLTERANLrsGAVRKLCRLDGVPVSSGKELVNGEYYVAIGVEKYKN 974  green sea turtle
OCT94868      131 PCVIHVFRNGDLMTPPYRVLLYPiiLKEWELVLSLLTQKVNLnsGAVRKLCTLDGVSLSNGAELVSGEYYVALGSEKYKC 210  African clawe...
XP_014348351  134 PCVINVFRNGDLLSPPFRLLIVKnmLQNWEKVLTLVNEKASLrtGAVRKLCTVDGIPLSCGEELKSGQYYVAVGAEKYKD 213  coelacanth
NP_001032778  128 PCIIHVFRNGDILSPAMRLIIPRhmLKNLEQILSLISEKAMLrtGAVRRICTLEGFTVTSAEELETGQCYVAVGSERFKK 207  zebrafish

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