3PVL,5F3Y


Conserved Protein Domain Family
FERM1_F1_Myosin-VII

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cd17092: FERM1_F1_Myosin-VII 
Click on image for an interactive view with Cn3D
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
This family includes two nontraditional members of the myosin superfamily, myosin-VIIa and myosin-VIIb. Myosin-VIIa, also termed myosin-7a (Myo7a), has been implicated in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and balance. Mutations in the MYO7A gene may be associated with Usher Syndrome type 1B (USH1B) and nonsyndromic hearing loss (DFNB2, DFNA11). Myosin-VIIb, also termed myosin-7b (Myo7b), is a high duty ratio motor adapted for generating and maintaining tension. It associates with harmonin and ANKS4B to form a stable ternary complex for anchoring microvilli tip-link cadherins. Like other unconventional myosins, myosin-VII is composed of a conserved motor head, a neck region and a tail region containing two MyTH4 domains, a SH3 domain, and two FERM domains. The FERM domain is made up of three sub-domains, F1, F2, and F3. The family corresponds to the F1 sub-domain of the first FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).
Statistics
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PSSM-Id: 340612
Aligned: 31 rows
Threshold Bit Score: 122.363
Created: 26-Oct-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
polypeptidekey conserved
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:3PVL; Mus musculus myosin VIIa MyTH4-FERM-SH3 in complex with the Cen1 of Sans, contacts at 4A.

cd17092 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd17092 is a member of the superfamily cl28922
Sub-family Hierarchy
cd00196Ubiquitin_like_foldcd01611Ubl_Autophagy_likecd01612Ubl_ATG12cd16108Ubl_ATG8_likecd16127Ubl_ATG8_GABARAP_likecd17232Ubl_ATG8_GABARAPcd17233Ubl_ATG8_GABARAPL1_likecd16128Ubl_ATG8cd16129Ubl_ATG8_MAP1LC3cd17234Ubl_ATG8_MAP1LC3Acd17235Ubl_ATG8_MAP1LC3Bcd17236Ubl_ATG8_MAP1LC3Ccd17163Ubl_ATG8_GABARAPL2cd01616TGScd01667TGS_ThrRScd01668TGS_RSHcd04938TGS_Obgcd01666TGS_DRGcd17230TGS_DRG1cd17231TGS_DRG2cd01669TGS_MJ1332_likecd04867TGS_YchF_OLA1cd01617DCXcd16109DCX1cd16112DCX1_DCXcd17140DCX1_DCLK1cd17141DCX1_DCLK2cd16110DCX1_RP_likecd17145DCX1_RP1cd17146DCX1_RP1L1cd16111DCX_DCLK3cd16113DCX2_DCDC2_likecd17152DCX2_DCDC2cd17153DCX2_DCDC2Bcd17154DCX2_DCDC2Ccd17069DCX2cd17142DCX2_DCXcd17143DCX2_DCLK1cd17144DCX2_DCLK2cd17070DCX2_RP_likecd17147DCX2_RP1cd17148DCX2_RP1L1cd17071DCX1_DCDC2_likecd17149DCX1_DCDC2cd17150DCX1_DCDC2Bcd17151DCX1_DCDC2Ccd17072DCX_DCDC5_likecd17155DCX_DCDC1cd17156DCX1_DCDC5cd17157DCX2_DCDC5cd17158DCX3_DCDC5cd17159DCX4_DCDC5cd17073KHAcd01760RBDcd01816RBD_RAFcd17133RBD_ARAFcd17134RBD_BRAFcd17135RBD_CRAFcd01817RBD1_RGS12_likecd17136RBD1_RGS12cd17137RBD1_RGS14cd17067RBD2_RGS12_likecd17138RBD2_RGS12cd17139RBD2_RGS14cd17068RBD_PLEKHG5cd01763Ubl_SUMO_likecd16114Ubl_SUMO1cd16115Ubl_SUMO2_3_4cd16116Ubl_Smt3_likecd17078Ubl_SLD1_NFATC2ipcd17079Ubl_SLD2_NFATC2ipcd17080Ubl_SLD2_Esc2_likecd01766Ubl_UFM1cd01767UBXcd01770UBX_UBXN2cd17160UBX_UBXN2Acd17161UBX_UBXN2Bcd17162UBX_UBXN2Ccd01771UBX_UBXN3Acd01772UBX_UBXN1cd01773UBX_UBXN7cd01774UBX_UBXN8cd16117UBX_UBXN4cd16118UBX2_UBXN9cd16119UBX_UBXN6cd16120UBX_UBXN3Bcd17075UBX1_UBXN9cd17076UBX_UBXN10cd17077UBX_UBXN11cd01768RA_FERM_F0_F1_likecd01765FERM_F0_F1cd17088FERM_F1_FRMPD1_likecd17168FERM_F1_FRMPD1cd17169FERM_F1_FRMPD3cd17170FERM_F1_FRMPD4cd17089FERM_F0_TLNcd17171FERM_F0_TLN1cd17172FERM_F0_TLN2cd17090FERM_F1_TLNcd17173FERM_F1_TLN1cd17174FERM_F1_TLN2cd17091FERM_F0_SHANKcd17175FERM_F0_SHANK1cd17176FERM_F0_SHANK2cd17177FERM_F0_SHANK3cd17092FERM1_F1_Myosin-VIIcd17093FERM2_F1_Myosin-VIIcd17094FERM_F1_Max1_likecd17178FERM_F1_PLEKHH1cd17179FERM_F1_PLEKHH2cd17095FERM_F0_kindlinscd17180FERM_F0_KIND1cd17181FERM_F0_KIND2cd17182FERM_F0_KIND3cd17096FERM_F1_kindlinscd17183FERM_F1_KIND1cd17184FERM_F1_KIND2cd17185FERM_F1_KIND3cd17097FERM_F1_ERM_likecd17186FERM_F1_Merlincd17187FERM_F1_ERMcd17237FERM_F1_Moesincd17238FERM_F1_Radixincd17239FERM_F1_Ezrincd17098FERM_F1_FARP1_likecd17188FERM_F1_FRMD7cd17189FERM_F1_FARP1cd17190FERM_F1_FARP2cd17099FERM_F1_PTPN14_likecd17191FERM_F1_PTPN14cd17192FERM_F1_PTPN21cd17100FERM_F1_PTPN3_likecd17193FERM_F1_PTPN3cd17194FERM_F1_PTPN4cd17101FERM_F1_PTPN13_likecd17195FERM_F1_PTPN13cd17196FERM_F1_FRMPD2cd17197FERM_F1_FRMD1cd17198FERM_F1_FRMD6cd17102FERM_F1_FRMD3cd17103FERM_F1_FRMD4cd17199FERM_F1_FRMD4Acd17200FERM_F1_FRMD4Bcd17104FERM_F1_MYLIPcd17105FERM_F1_EPB41cd17106FERM_F1_EPB41Lcd17201FERM_F1_EPB41L1cd17202FERM_F1_EPB41L2cd17203FERM_F1_EPB41L3cd17107FERM_F1_EPB41L4Acd17108FERM_F1_EPB41L5_likecd17204FERM_F1_EPB41L4Bcd17205FERM_F1_EPB41L5cd17109FERM_F1_SNX17_likecd01777FERM_F1_SNX27cd16121FERM_F1_SNX17cd16122FERM_F1_SNX31cd17110FERM_F1_Myo10_likecd17206FERM_F1_Myosin-Xcd17207FERM_F1_PLEKHH3cd17208FERM_F1_DdMyo7_likecd17043RAcd00153RA_RalGDS_likecd17209RA_RalGDScd17210RA_RGLcd17211RA_RGL2cd17212RA_RGL3cd01775RA_PHLPP_likecd17213RA_PHLPPcd17240RA_PHLPP1cd17241RA_PHLPP2cd17214RA_CYR1_likecd01776RA_Rincd16130RA_Rin3cd16131RA_Rin2cd17215RA_Rin1cd01778RA_RASSF1_likecd17218RA_RASSF1cd17219RA_RASSF3cd17220RA_RASSF5cd01779RA_Myosin-IXcd17216RA_Myosin-IXacd17217RA_Myosin-IXbcd01781RA2_Afadincd01782RA1_Afadincd01783RA2_DAGK-thetacd01784RA_RASSF2_likecd17221RA_RASSF2cd17222RA_RASSF4cd17223RA_RASSF6cd01785RA_PDZ-GEF1cd01786RA_STE50cd16123RA_RASSF7_likecd16132RA_RASSF10cd16133RA_RASSF9cd16134RA_RASSF8cd16135RA_RASSF7cd16125RA_ASPP1_2cd17224RA_ASPP1cd17225RA_ASPP2cd17111RA1_DAGK-thetacd17112RA_MRL_likecd01787RA_MRLcd16136RA_MRL_Lpdcd16137RA_MRL_RIAMcd16138RA_MRL_MIG10cd16124RA_GRB7_10_14cd16139RA_GRB14cd16140RA_GRB7cd16141RA_GRB10cd17113RA_ARAPscd17226RA_ARAP1cd17227RA_ARAP2cd17228RA_ARAP3cd17114RA_PLC-epsiloncd01780RA2_PLC-epsiloncd17229RA1_PLC-epsiloncd17115RA_RHG20cd17116RA_Radil_likecd17117RA_ANKFN1_likecd16102RAWUL_PCGF_likecd17081RAWUL_PCGF1cd17082RAWUL_PCGF2_likecd17164RAWUL_PCGF2cd17165RAWUL_PCGF4cd17083RAWUL_PCGF3cd17084RAWUL_PCGF5cd17085RAWUL_PCGF6cd17086RAWUL_RING1_likecd17166RAWUL_RING1cd17167RAWUL_RING2cd17087RAWUL_DRIP_likecd16105Ubl_ASPSCR1_likecd17039Ubl_ubiquitin_likecd01788Ubl_ElonginBcd01789Ubl_TBCBcd01790Ubl_HERPcd17118Ubl_HERP1cd17119Ubl_HERP2cd01791Ubl_UBL5cd01792Ubl1_ISG15cd01793Ubl_FUBIcd01794Ubl_UBTDcd17120Ubl_UBTD1cd17121Ubl_UBTD2cd01795Ubl_USP48cd01796Ubl_Ddi1_likecd01797Ubl_UHRFcd17122Ubl_UHRF1cd17123Ubl_UHRF2cd01798Ubl_parkincd01799Ubl_HOIL1cd01800Ubl_SF3a120cd01801Ubl_TECR_likecd17124Ubl_TECRcd17125Ubl_TECRLcd01802Ubl_ZFAND4cd01803Ubl_ubiquitincd01804Ubl_midnolincd01805Ubl_Rad23cd16126Ubl_HR23Bcd17126Ubl_HR23Acd01806Ubl_NEDD8cd01807Ubl_UBL4A_likecd01808Ubl_PLICscd01809Ubl_BAG6cd01810Ubl2_ISG15cd01811Ubl1_OASLcd01812Ubl_BAG1cd01813Ubl_UBLCP1cd01814Ubl_MUBs_plantcd01815Ubl_UBL7cd12219Ubl_TBK1_likecd17127Ubl_TBK1cd17128Ubl_IKKEcd16103Ubl2_OASLcd16104Ubl_USP14_likecd16106Ubl_Dsk2p_likecd16107Ubl_AtUPL5_likecd17044Ubl_TBCEcd17045Ubl_TBCELcd17046Ubl_IKKA_likecd17047Ubl_UBFD1cd17048Ubl_UBL3cd17049Ubl_Sacsincd17050Ubl1_ANKUB1cd17051Ubl2_ANKUB1cd17052Ubl1_FAT10cd17053Ubl2_FAT10cd17054Ubl_AtBAG1_likecd17055Ubl_AtNPL4_likecd17056Ubl_FAF1cd17129Ubl1_FAF1cd17130Ubl2_FAF1cd17057Ubl_TMUB1_likecd17131Ubl_TMUB1cd17132Ubl_TMUB2cd17058Ubl_SNRNP25cd17059Ubl_OTU1cd17060Ubl_RB1CC1cd17061Ubl_IQUBcd17062Ubl_NUB1cd17063Ubl_ANKRD60cd17064Ubl_TAFs_likecd17065Ubl_UBP24cd17066Ubl_KPC2cd17040Ubl_MoaD_likecd00565Ubl_ThiScd00754Ubl_MoaDcd01764Ubl_Urm1cd17074Ubl_CysO_likecd17505Ubl_SAMP1_likecd17506Ubl_SAMP2_likecd17041Ubl_WDR48cd17042Ubl_TmoB
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                            ######      #       #        
3PVL_A        263 PIMLPVTFMdGTTKTLLTDSATTARELCNALADKISLKDr-FGFSLYIALFDKVSSLGs--GSDHVMDAISQCEQYAKEq 339  house mouse
5F3Y_A        236 HIPIQVILAtGRSLTISVDSASTSREICQHVAQKQGLRDn-LGFSLQVAVYDKFWSLGs--GCDHLMDAVAQCEQLAREr 312  house mouse
XP_001747018  121 PIRLQVDFF-VDRVNVELDSQTTARELLEQIYAQSALARe-AGFSIYVADTDGDMMTScgaGDTFVLDIVFQYETLASAr 198  Monosiga brev...
Q6PIF6       1196 HIPIQVILAtGESLTVPVDSASTSREMCMHIAHKQGLSDh-LGFSLQVAVYDKFWSLGs--GRDHMMDAIARCEQMAQEr 1272 human
CBY40452      491 QIQVRVSLMdKTVHQVKADSATTAKEICREIASLAGLDEgtYGFGLFISIFQRVSSLGg--GREHLMDAIAQCEQISVEh 568  Oikopleura di...
EKC42413      693 PILIPMSMMnGQRMIVEADSASTVQELVHQICHKAGLQDs-SGFSIYITLMQRISCLGn--GTHRVMDAVAECEQHTKQs 769  Pacific oyster
CDS32039     1369 SLGVNVICAtGSRVRVKVDPTITVKEFTKMTFNEASIKDt-FGFEIFIKMFDKVEALSs--DTKYFFDKISQCQEVMKRe 1445 Hymenolepis m...
KXJ11793      237 KIMIPIITMdSKTYEFEVDSSTTCEELLKDFQSKLGLKNi-FGFSVFAKQFEEVFNWGc--GSDCIMDLISLCEQYAIYk 313  Exaiptasia pa...
XP_001627347   91 NIVLPVTLMdGATLDCEVDANSTFKELCESIREKLGLKSi-YGFSIYIAAVDQIFNWGs--DDENVMDAVSLAERYSVRk 167  starlet sea a...
XP_015761896  235 SPAVPVTFMdGSTKLFQVDPATTCAELCQLIKLSLGIKSi-FGFSIYVASLEQVANWGc--GTESIFDAVSLAEQYGQTk 311  Acropora digi...
Feature 1                           #        
3PVL_A        340 gaq-----ernAPWRLFFRKEVFTPWH 361  house mouse
5F3Y_A        313 ges-----qrqAPWRIYFRKEFFTPWH 334  house mouse
XP_001747018  199 fqgswqrlaqeRPFQLLLRKEMFAPWF 225  Monosiga brevicollis MX1
Q6PIF6       1273 ges-----qrqSPWRIYFRKEFFTPWH 1294 human
CBY40452      569 sla-----aesAPWQIIFRKEVFSPWY 590  Oikopleura dioica
EKC42413      770 gmr-----essSSWRLYFRKEYFLPWH 791  Pacific oyster
CDS32039     1446 grk-----eseLPWSLSIKKTIFAPWH 1467 Hymenolepis microstoma
KXJ11793      314 hvs----eeerHNWTIFVRKDVFLSSH 336  Exaiptasia pallida
XP_001627347  168 gnp-----esdTKLHFYLRKNIFRPSY 189  starlet sea anemone
XP_015761896  312 ike-----dgsDTWKIYFRKDLFEPVV 333  Acropora digitifera

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