5Z38,3EPU,1K3E,5WEZ


Conserved Protein Domain Family
T3SC_IA_CesT-like
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cd17023: T3SC_IA_CesT-like 
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Class IA type III secretion system chaperone protein, similar to Escherichia coli CesT
This family includes type III secretion system (T3SS) chaperone proteins similar to Escherichia coli CesT and also contains Stm2138, a novel virulence chaperone in Salmonella enterica subsp. enterica serovar Typhimurium. In E. coli, the T3SS allows injection of the effector Tir (translocated intimin receptor), which plays a key role in enterohemorrhagic Escherichia coli (EHEC) infection, attaching and effacing (A/E) lesions, and intracellular signal transduction. CesT binds to Tir, which interacts with intimin and anchors the infected cell membrane inside the host cytoplasm for signaling.
Links
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Statistics
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PSSM-Id: 409307
Aligned: 7 rows
Threshold Bit Score: 197.302
Created: 4-Feb-2016
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:3EPU: Salmonella enterica Stm2138, a novel virulence chaperone, homodimer; contacts at 4.0A
  • Comment:Shows domain swap in CesT, which may either provide an alternative dimerization pattern to facilitate interaction with its target effector protein, Tir, or it may be a crystallographic artifact. Likely, in absence of domain-swap event, CesT may form dimers similar to other chaperones such as SigE
  • Structure:1K3E: Escherichia coli type III secretion chaperone CesT homodimer; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     # #                 ### ### ##     
5Z38_A         5 SRSELLLDRFAEKIGVgSISFNENRLCSFAIDEiYYISLSDANDEYMMIYGVCGKFPtd---npNFALEILNANLWfaen 81  Escherichia coli
3EPU_A         3 SRADRLLRQFSLKLNTdSIVFDENRLCSFIIDNrYRILLTSTNSEYIMIYGFCGKPPdn----nNLAFEFLNANLWfaen 78  Salmonella ente...
Q47015         3 SRSELLLDRFAEKIGIgSISFNENRLCSFAIDEiYYISLSDANDEYMMIYGVCGKFPtd---npNFALEILNANLWfaen 79  Escherichia coli
WP_154147990   1 MKSDKVLKDFGEHIGIrNMIFDHKRSCSIVVANdNIIIINDVQDTALMINCIVGPVDkkniadsKTTMKLLSMNMLfaae 80  Ewingella ameri...
WP_048030910   1 MSTEELLKQFGEHIGIrHLRLEVNRSCQLRFGDdLWVIINEVNAERLLLNAVVGRIPpqt--adQLAFTLLNMNMLfahv 78  Leclercia
1K3E_A         3 SRSELLLEKFAEKIGIgSISFNENRLCSFAIDEiYYISLSDANDEYMMIYGVCGKFPtd---nsNFALEILNANLWfaen 79  Escherichia col...
5WEZ_A         4 SRSELLLDRFAEKIGVgSISFNENRLCSFAIDEiYYISLSDANDEYMMIYGVCGKFPtd---npNFALEILNANLWfaen 80  Escherichia col...

Feature 1         ###### #     # # #                                     
5Z38_A        82 gGPYLCYESgAQSLLLALRFPLDDATPEKLENEIEVVVKSMENLYLVLHNQGITLE 137 Escherichia coli
3EPU_A        79 nGPHLCYDNnSQSLLLALNFSLNESSVEKLECEIEVVIRSMENLYHILQDKGITLD 134 Salmonella enterica subsp. enterica ser...
Q47015        80 gGPYLCYESgAQSLLLALRFPLDDATPEKLENEIEVVVKSMENLYLVLHNQGITLE 135 Escherichia coli
WP_154147990  81 nGPYVGFEPtQNTVVLSVTTNLEEATPLVMESQISYLLKNKWLVRASLEESGCVLA 136 Ewingella americana
WP_048030910  79 eGPYVTCEPeRNIIMLSRALEIAGLDVLAIEENISYLLQNVEHIRVILQEKGISLD 134 Leclercia
1K3E_A        80 gGPYLCYEAgAQSLLLALRFPLDDATPEKLENEIEVVVKSMENLYLVLHNQGITLE 135 Escherichia coli O157:H7
5WEZ_A        81 gGPYLCYESgAQSLLLALRFPLDDATPEKLENEIEVVVKSMENLYLVLHNQGITLE 136 Escherichia coli O127:H6 str. E2348/69

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