3RLS,3FK3,3QRL,5D7E,5HJB,5IOK,5IQL


Conserved Protein Domain Family
YEATS
?
cd16887: YEATS 
Click on image for an interactive view with Cn3D
YEATS domain family, chromatin reader proteins
The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.
Links
?
Statistics
?
PSSM-Id: 341123
Aligned: 41 rows
Threshold Bit Score: 94.6521
Created: 11-Jul-2015
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: putative peptide binding site [polypeptide binding site], 9 residue positions
Conserved feature residue pattern:[HRK] H [TS] [FY] G [YW] [AG] [EG] FClick to see conserved feature residue pattern help
Evidence:
  • Structure:5IOK: Saccharomyces cerevisiae Taf14 binds histone H3k9cr; contacts at 4A
  • Structure:5IOK: Saccharomyces cerevisiae Taf14 binds histone H3k9ac; contacts at 4A
  • Structure:5HJB: human Af9 binds histone H3 crotonylation at K18; contacts at 4A
  • Structure:5IQL: human Yeats2 binds H3k27cr peptide; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              #      
3RLS_A      8 RPIIYGNTAKKMgsvkppn------------------------------------------------apaehtHLWTIFV 39  baker's yeast
5HJB_A     11 VKLELGHRAQVRkkptv----------------------------------------------------egftHDWMVFV 38  human
5IOK_A     12 RTIRIKTQQHILpevppv--------------------------------------------------enfpvRQWSIEI 41  Saccharomyces cere...
5IQL_A      9 KTIVVGNVSKYIppdkre-------------------------------------------------endqstHKWMVYV 39  human
EJW03862   12 RGLIVGTKSKKIhkpv-----------------------------------------------------ddntHEWSVYV 38  Edhazardia aedis U...
KJE91602    8 RKILVGNEIEAIppklvn--------------------------------------------------nathtYRWTVFV 37  Capsaspora owczarz...
KPI87966   17 IPYAIGSVAIPIskaysssadgidhagtegegksssgrpgmqsseqaqragrsdptkrrgvtsgninsvrrctHHRYCYL 96  Leptomonas seymouri
EAY16198   10 KELIFSHLARRLakqt-----------------------------------------------------qfktHHWEIFL 36  Trichomonas vagina...
ODQ54238  269 CRIVVGNVSKYLqrhersp------------------------------------------------dnpkctHKWLLYI 300 Saitoella complica...
EET01955   23 KGVCAGFVRFKLarppv---------------------------------------------------kdvawHCWTIFL 51  Giardia intestinal...

Feature 1                                                                            #  ##    
3RLS_A     40 RGpqne----------------------------------------------------disYFIKKVVFKLHd-TYPn-P 65  baker's yeast
5HJB_A     39 RGpehs----------------------------------------------------niqHFVEKVVFHLHe-SFPr-P 64  human
5IOK_A     42 VLlddeg-------------------------------------------------keipaTIFDKVIYHLHp-TFAn-P 70  Saccharomyces cere...
5IQL_A     40 RGsrre---------------------------------------------------psinHFVKKVWFFLHp-SYKpnD 67  human
EJW03862   39 QSpfs-----------------------------------------------------tslDYIQNVVFKLHe-TFDe-P 63  Edhazardia aedis U...
KJE91602   38 RSesptt--------------------------------------------------fdlsSVVSRVEFQLLegHFKn-P 66  Capsaspora owczarz...
KPI87966   97 RDggaleqdafyrwlqhlrseittetkgstvgnsaddcspkaspvsassdaaepqspsplyASLACVVFLLPs-SFPh-P 174 Leptomonas seymouri
EAY16198   37 YSptge----------------------------------------------------dlsKWIDCVTFRLHe-SFEr-P 62  Trichomonas vagina...
ODQ54238  301 NApays---------------------------------------------------qpvsTFVRAVTLTLDp-SFP--P 326 Saitoella complica...
EET01955   52 ASncgl----------------------------------------------------dlsPFVEKVTFVIHk-DFSs-Y 77  Giardia intestinal...

Feature 1                     #####                                                           
3RLS_A     66 VRSIEa--PPFELTETGWGEFDINIKVYFveeanekVLNFYHRLRlhpyanpvpnsdngn-------------------- 123 baker's yeast
5HJB_A     65 KRVCKd--PPYKVEESGYAGFILPIEVYFknkeeprKVRFDYDLFlhleg------------------------------ 112 human
5IOK_A     71 NRTFTd--PPFRIEEQGWGGFPLDISVFLlek--agERKIPHDLNflq-------------------------------- 114 Saccharomyces cere...
5IQL_A     68 LVEVRe--PPFHLTRRGWGEFPVRVQVHFkds-qnkRIDIIHNLKldrtyt----------------------------- 115 human
EJW03862   64 VVTKT---YPFEVKKKGWGEFTIQIRINFvdp-nekPLNLLQTLVlhdgvin---------------------------- 111 Edhazardia aedis U...
KJE91602   67 RRQISs--PPYQVVETGWGSFDIPITVYFkda-sqaPVKFVHPLHfptvd------------------------------ 113 Capsaspora owczarz...
KPI87966  175 RRVLRr--PPYLIEDDTWAEHMVEVQMHFlshlripPVTLVHQALlerrtppllravtaatdgaaaalvkregepereev 252 Leptomonas seymouri
EAY16198   63 ERPMTh--EPYRVSEDGWGEFEARIDIAPkn---aiPITLVHNITfppqns----------------------------- 108 Trichomonas vagina...
ODQ54238  327 PHEITldrAPFKYLSQGWGDFMLKIRISLlds-rnkDINIVHPVKldphhtg---------------------------- 377 Saitoella complica...
EET01955   78 VRSVYd--PPYETTVIGQLGFEAFIHVTYrds-klpPSIISINIVidgd------------------------------- 123 Giardia intestinal...

Feature 1                                                                                     
3RLS_A    124 -------------------------------------------------------------------eqnttdhnskdae 136 baker's yeast
5HJB_A    113 -----------------------------------------------------------------------------hpp 115 human
5IOK_A        --------------------------------------------------------------------------------     Saccharomyces cere...
5IQL_A    116 ----------------------------------------------------------------------------glqt 119 human
EJW03862  112 ----------------------------------------------------------------------------edgf 115 Edhazardia aedis U...
KJE91602  114 -----------------------------------------------------------------------------nts 116 Capsaspora owczarz...
KPI87966  253 reiwvpqllassfgkpklppvpsnvvvqhfsnlasgsihvidtsttaaaaeppahsstkppshhhhhhygnggtvagttv 332 Leptomonas seymouri
EAY16198  109 ----------------------------------------------------------------------------vkpc 112 Trichomonas vagina...
ODQ54238  378 ---------------------------------------------------------------------------kevls 382 Saitoella complica...
EET01955  124 ------------------------------------------------------------------------------dy 125 Giardia intestinal...

Feature 1                 
3RLS_A    137 vsSVYFDEIVFN 148 baker's yeast
5HJB_A    116 vnHLRCEKLTFN 127 human
5IOK_A    115 esYEVEHVIQIP 126 Saccharomyces cerevisiae S288c
5IQL_A    120 lgAETVVDVELH 131 human
EJW03862  116 lvSERYEEIVFR 127 Edhazardia aedis USNM 41457
KJE91602  117 nlQQKTHTLTFV 128 Capsaspora owczarzaki ATCC 30864
KPI87966  333 vvTEKVDTLRLY 344 Leptomonas seymouri
EAY16198  113 iiERKRMKIVFR 124 Trichomonas vaginalis G3
ODQ54238  383 seSLFDVELDRD 394 Saitoella complicata NRRL Y-17804
EET01955  126 tqRIYPDMLVFV 137 Giardia intestinalis ATCC 50581

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap