Conserved Protein Domain Family
RING-H2_RNF150
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cd16805: RING-H2_RNF150 
RING finger, H2 subclass, found in RING finger protein 150 (RNF150) and similar proteins
RNF150 is a RING finger protein and its polymorphisms may be associated with chronic obstructive pulmonary disease (COPD) risk in the Chinese population. Further studies with larger numbers of participants worldwide are needed for validation of the relationships between RNF150 genetic variants and the pathogenesis of COPD. RNF150 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain followed by a putative PEST sequence.
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Statistics
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PSSM-Id: 438456
Aligned: 6 rows
Threshold Bit Score: 115.922
Created: 19-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  #              # #  #  #          #  #      
Q9ULK6       270 ETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILK 324 human
Q566M8       259 ETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKCCVDPWLVDHRTCPMCKMNILK 313 zebrafish
XP_006008995 236 ETDSDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILK 290 coelacanth
XP_007895841 266 ETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKTCVDPWLLDHRTCPMCKMNILK 320 elephant shark
NP_001135553 260 ETEPEFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILK 314 western clawed frog
XP_003641201 264 ETEPDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILK 318 chicken

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