Conserved Protein Domain Family
RING-H2_RNF130
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cd16803: RING-H2_RNF130 
RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins
RNF130, also known as Goliath homolog (H-Goliath), is a paralog of RNF128, also known as gene related to anergy in lymphocytes protein (GRAIL). It is a transmembrane E3 ubiquitin-protein ligase expressed in leukocytes. It has a self-ubiquitination property, and controls the development of T cell clonal anergy by ubiquitination. RNF130 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain followed by a putative PEST sequence.
Links
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Statistics
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PSSM-Id: 319717
Aligned: 6 rows
Threshold Bit Score: 120.077
Created: 19-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #              # #  #  #          #  #      
Q86XS8       262 DHCAVCIESYKqnDVVRILPCKHVFHKSCVDPWLsEHCTCPMCKLNILK 310 human
XP_005988331 266 DHCAVCIEGYKlnDVVRILPCKHVFHKNCVDPWLnEQCTCPMCKLNILK 314 coelacanth
KFV61298     274 DHCAVCIESYKqnDVVRILPCKHVFHKACVDPWLsEHCTCPMCKLNILK 322 downy woodpecker
XP_007906320 272 DHCAVCIEGYKsnDVVRILPCKHLFHKSCVDPWLnEHCTCPICKLNILK 320 elephant shark
NP_001018301 235 NHCAVCIEGYQlnDVVRILPCKHVFHKMCVDPWLnEHCTCPMCKLNILK 283 zebrafish
AAI35902     267 DHCAVCIESYKqnDIVRVLPCKHVFHKVCVDPWLsEHCTCPMCKLNILK 315 western clawed frog

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