Conserved Protein Domain Family
mRING-HC-C3HC5_NEU1A
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cd16785: mRING-HC-C3HC5_NEU1A 
Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins
NEURL1A, also known as NEURL1, NEU, neuralized 1, or RING finger protein 67 (RNF67), is a mammalian homolog of the Drosophila neuralized (D-neu) protein. It functions as an E3 ubiquitin-protein ligase that directly interacts with and monoubiquitinates cytoplasmic polyadenylation element-binding protein 3 (CPEB3), an RNA binding protein and a translational regulator of local protein synthesis, which facilitates hippocampal plasticity and hippocampal-dependent memory storage. It also acts as a potential tumor suppressor that causes apoptosis and downregulates Notch target genes in the medulloblastoma. NEURL1A contains two neuralized homology regions (NHRs) responsible for Neural-ligand interactions and a modified C3HC5-type RING-HC finger required for ubiquitin ligase activity. The C3HC5-type RING-HC finger is distinguished from typical C3HC4-type RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
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Statistics
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PSSM-Id: 438439
Aligned: 3 rows
Threshold Bit Score: 129.716
Created: 29-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:modified RING-HC finger (C3HC5-type), extra conserved cysteine is not involved in Zn binding
  • Comment:The C3HC5-type RING finger is distinguished from typical C3HC4 RING-HC finger and C3H2C3 RING-H2 finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  #           # #   #  #           #  #             
O76050       515 GQWSDECTICYEHaVDTVIYTCGHMCLCYACGLRLKKAlHACCPICRRPIKDIIKTYRS 573 human
NP_001071026 499 GSWLDECSICYENtVDTVIYTCGHMCLCYTCGLRLKKMaNASCPICRRAIKDIIKTYRS 557 zebrafish
XP_005995883 494 GSWSEECTICYENvVDTVIYACGHMCLCYPCGRKLKQMsNACCPICRRAIKDIIKTYRS 552 coelacanth

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