Conserved Protein Domain Family
RING-HC_TIF1alpha
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cd16764: RING-HC_TIF1alpha 
RING finger, HC subclass, found in transcription inknown asiary factor 1-alpha (TIF1-alpha)
TIF1-alpha, also known as tripartite motif-containing protein 24 (TRIM24), E3 ubiquitin-protein ligase TRIM24, or RING finger protein 82, belongs to the C-VI subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. It interacts specifically and in a ligand-dependent manner with the ligand binding domain (LBD) of several nuclear receptors (NRs), including retinoid X (RXR), retinoic acid (RAR), vitamin D3 (VDR), estrogen (ER), and progesterone (PR) receptors. It also associates with heterochromatin-associated factors HP1alpha, MOD1 (HP1beta), and MOD2 (HP1gamma), as well as the vertebrate Kruppel-type (C2H2) zinc finger proteins that contain the transcriptional silencing domain KRAB. TIF1-alpha is a ligand-dependent co-repressor of RAR that interacts with multiple nuclear receptors in vitro via an LXXLL motif and further acts as a gatekeeper of liver carcinogenesis. It also functions as an E3-ubiquitin ligase targeting p53, and is broadly associated with chromatin silencing. Moreover, it is a chromatin regulator that recognizes specific, combinatorial histone modifications through its C-terminal PHD-Bromo region. In addition, it interacts with chromatin and estrogen receptor to activate estrogen-dependent genes associated with cellular proliferation and tumor development.
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Statistics
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PSSM-Id: 438420
Aligned: 4 rows
Threshold Bit Score: 108.025
Created: 22-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of Homo sapiens TRIM28 with bound Zn2+ ions through its RING-HC finger
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #             # #  #  #                                             #  #  
O15164         53 LDTCAVCHQNIQsRAPKLLPCLHSFCQRCLPAPQRYLMLpapmlgsaetpppvpapgspvsgsspfatqvGVIRCPVCSQ 132  human
NP_001088294   47 LETCGLCRTHIQsRSPRLLPCLHSLCQRCLPPPERFLSVsdprppdp----------------saaplqvGVIRCPVCSQ 110  African clawe...
ETE59488       43 LDTCGVCGQHIQsRRPKLLPCLHSFCQRCLPSPHRYLMLpppaapspggaaa-----atapavlgafftvGVVRCPICGQ 117  king cobra
XP_014349045   39 LDTCAVCKQILQsREPRLLPCLHSFCDKCLPQPERHLVLpahfsqpggp-----------rataspnrqiGVVRCPVCNQ 107  coelacanth

Feature 1           
O15164        133 EC 134  human
NP_001088294  111 EC 112  African clawed frog
ETE59488      118 EC 119  king cobra
XP_014349045  108 EC 109  coelacanth

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