Conserved Protein Domain Family
RING-HC_SH3RF3
?
cd16750: RING-HC_SH3RF3 
RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
SH3RF3, also known as plenty of SH3s 2 (POSH2) or SH3 multiple domains protein 4 (SH3MD4), is a scaffold protein with E3 ubiquitin-protein ligase activity. It was identified in a screen for interacting partners of p21-activated kinase 2 (PAK2). It may play a role in regulating c-Jun N-terminal kinase (JNK) mediated apoptosis in certain conditions. It also interacts with GTP-loaded Rac1. SH3RF3 is highly homologous to SH3RF1. Both contain an N-terminal C3HC4-type RING-HC finger responsible for the E3 ligase activity and four Src Homology 3 (SH3) domains, which are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs.
Links
?
Statistics
?
PSSM-Id: 438408
Aligned: 13 rows
Threshold Bit Score: 87.8648
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #            # #  #  #            #  # 
Q8TEJ3         53 DLLECSVCLERLDttaKVLPCQHTFCRRCLESIvcsrhELRCPECR 98   human
AAF37265        8 DLLECSVCLERLDttsKVLPCQHTFCRKCLQDIvasqhKLRCPECR 53   fruit fly
ELU13626        8 ELLECSVCLDQLDhssKVLPCQHTFCRRCLEEIvsakdELRCPECR 53   Capitella sp. I Grassle & Grassle, 1976
EFX81681        8 DLLECSVCLERLDissRVLPCQHTFCKKCLEEIittqkELRCPECR 53   common water flea
XP_003218783   46 DLLECSVCLERLDttaKVLPCQHTFCRRCLESIvssrhELRCPECR 91   green anole
NP_001090115    8 DLLECSVCLERLDtsaRVLPCQHTFCRRCLHSIvssrnELRCPECR 53   African clawed frog
EEC20522       11 DLLECSVCLEQLDstsKVLPCQHTFCKRCLDEIvhshkELRCPECR 56   black-legged tick
XP_006813628    8 DLLECSVCLERLDessKVLPCQHTFCKRCLEEIvnsrkELRCPECR 53   Saccoglossus kowalevskii
XP_006009608    8 DLLECSVCLERLDtsaKVLPCQHTFCRRCLENIvssrnELRCPECR 53   coelacanth
XP_007902615    8 DLLECSVCLERLDttaKVLPCQHTFCKRCLEKIlssrnELRCPECR 53   elephant shark
XP_793907      11 DILECSVCLERLDatsRVLPCQHTFCQRCLQQIlntrgELRCPECR 56   purple urchin
XP_015133350    8 DLLECSVCLERLDttaKVLPCQHTFCRRCLESIvssrhELRCPECR 53   chicken
XP_002123694    8 DLLECSVCLKPLDqqnKVLPCQHTFCKSCLFSIvrshkELRCPECR 53   vase tunicate

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap