Conserved Protein Domain Family
RING-HC_AtRMA-like
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cd16745: RING-HC_AtRMA-like 
RING finger, HC subclass, found in Arabidopsis thaliana RING membrane-anchor proteins (AtRMAs) and similar proteins
AtRMAs, including AtRma1, AtRma2, and AtRma3, are endoplasmic reticulum (ER)-localized Arabidopsis homologs of human outer membrane of the ER-anchor E3 ubiquitin-protein ligase, RING finger protein 5 (RNF5). AtRMAs possess E3 ubiquitin ligase activity, and may play a role in the growth and development of Arabidopsis. The AtRMA1 and AtRMA3 genes are predominantly expressed in major tissues, such as cotyledons, leaves, shoot-root junction, roots, and anthers, while AtRMA2 expression is restricted to the root tips and leaf hydathodes. AtRma1 probably functions with the Ubc4/5 subfamily of E2. AtRma2 is likely involved in the cellular regulation of ABP1 expression levels through interacting with auxin binding protein 1 (ABP1). AtRMA proteins contain an N-terminal C3HC4-type RING-HC finger and a trans-membrane-anchoring domain in their extreme C-terminal region.
Links
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Statistics
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PSSM-Id: 438403
Aligned: 9 rows
Threshold Bit Score: 92.9322
Created: 9-Feb-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #  #           # #  #  #                          #  #  
Q8GUK7     42 FDCNICLDTahDPVVTLCGHLFCWPCIYKWLhvqlssv------svdqhqnNCPVCKS 93  thale cress
EGD77884   82 FSCNICLDAvsDPVVTRCGHLFCWPCLHEWLrr----------------kpDCPVCKA 123 Salpingoeca sp. ATCC50818
EFJ24309    7 YDCNICLELaqDPVVTHCGHLFCWPCLYRWLasrs-------------sctECPVCKS 51  Selaginella moellendorffii
ELR20732   26 FECNICFDTaqDPVVTLCGHLFCWPCIYKWLelhp-------------dqpSCPVCKA 70  Acanthamoeba castellanii str. Neff
ABK21979   42 FECNICLELaqDPIVTLCGHLFCWPCLYKWLhghs-------------ksqECPVCKA 86  Sitka spruce
EUT89352  284 FECNICFDDvrDPVVTKCGHLFCWLCLSAWIkk----------------nnDCPVCKA 325 Plasmodium falciparum Santa Lucia
EPR61454  347 FECNICFDEatDPVVTRCGHLFCWTCLHAWLrrg---------------tyECPVCKA 389 Toxoplasma gondii GT1
O64425     46 FDCNICLDSvqEPVVTLCGHLFCWPCIHKWLdvqsfsts-----deyqrhrQCPVCKS 98  thale cress
P93030     19 FDCNICLDQvrDPVVTLCGHLFCWPCIHKWTyasnnsrqrvdqydhkreppKCPVCKS 76  thale cress

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