Conserved Protein Domain Family
RING-HC_PCGF2
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cd16734: RING-HC_PCGF2 
RING finger found in polycomb group RING finger protein 2 (PCGF2) and similar proteins
PCGF2, also known as DNA-binding protein Mel-18, RING finger protein 110 (RNF110), or zinc finger protein 144 (ZNF144), is one of six PcG RING finger (PCGF) homologs (PCGF1/NSPc1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6/MBLR). It serves as the core component of a canonical Polycomb repressive complex 1 (PRC1), which is composed of a chromodomain-containing protein (CBX2, CBX4, CBX6, CBX7 or CBX8) and a Polyhomeotic protein (PHC1, PHC2, or PHC3). Like other PCGF homologs, PCGF2 associates with ring finger protein 2 (RNF2) to form a RNF2-PCGF heterodimer, which is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. Moreover, PCGF2 uniquely regulates PRC1 to specify mesoderm cell fate in embryonic stem cells. It is required for PRC1 stability and maintenance of gene repression in embryonic stem cells (ESCs) and essential for ESC differentiation into early cardiac-mesoderm precursors. PCGF2 also plays a significant role in the angiogenic function of endothelial cells (ECs) by regulating endothelial gene expression. Furthermore, PCGF2 is a SUMO-dependent regulator of hormone receptors. It facilitates the deSUMOylation process by inhibiting PCGF4/BMI1-mediated ubiquitin-proteasomal degradation of SUMO1/sentrin-specific protease 1 (SENP1). It is also a novel negative regulator of breast cancer stem cells (CSCs) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated Notch signaling. PCGF2 contains a C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438392
Aligned: 6 rows
Threshold Bit Score: 166.7
Created: 19-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of Homo sapiens PCGF4 with bound Zn2+ ions thorugh its RING-HC finger
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #  #            # #  #  #          #  #                         
P35227         2 HRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYK 81  human
XP_007902520   2 HRTTRIKITELNPHLMCALCGGYFIDATTIIECLHSFCKTCIVRYLETNKYCPICDVQVHKTRPLLSVRADKTLQDIVYK 81  elephant shark
NP_001268444   2 HRTTRIKITELNPHLMCALCGGYFIDAATIVECLHSFCKTCIVRYLEANKYCPMCDAQVHKTRPLLSIRSDRTLQDVVYK 81  chicken
NP_001084523   2 HRTTRIKMTELNPHLMCALCGGYFIDAATIVECLHSFCKTCILRYLEAHKFCPMCDSQVHKGRPLLSIRSDKTLQDIVYK 81  African clawed ...
XP_013388453   2 HRTTRLKITELNPHLMCALCGGYLTDAATVVECLHSFCKTCIVRYMETSKFCPICDVMVHKTKPLTNVRLDKTLQDLVYK 81  Lingula anatina
XP_006010900   2 HRTTRIKITELNPHLTCALCAGYFIDATTIVECLHSFCKTCIVPYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYK 81  coelacanth

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