variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein-like (IRF-2BPL)
IRF-2BPL, also known as C14orf4 or enhanced at puberty protein 1(EAP1), is a homolog of interferon regulatory factor 2-binding proteins, IRF-2BP1 and IRF-2BP2. It is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. IRF-2BPL is a proline-rich protein with polyglutamine and polyalanine tracks at the N-terminus and a C3HC4-type RING-HC finger domain with a partially new pattern at the C-terminus.
Structure:2CS3; Homo sapiens IRF-2BPL binds two Zn2+ ions through its RING-HC finger.
Comment:variant RING-HC finger (C3HC4-type)
Comment:typical C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Comment:The C3HC4-type RING-HC finger of Homo sapiens IRF-2BPL shows a partially new pattern by comparing with the typical C3HC4-type RING-HC finger. The third, sixth and seventh conserved Cys residues are in different positions.
Jiyao W et al.(2023). "The conserved domain database in 2023.",