Conserved Protein Domain Family
RING-HC_DTX3
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cd16711: RING-HC_DTX3 
RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
DTX3, also known as RING finger protein 154 (RNF154), is an E3 ubiquitin-protein ligase that belongs to the Deltex (DTX) family. In contrast to other DTXs, DTX3 does not contain two N-terminal Notch-binding WWE domains, but a short unique N-terminal domain, suggesting it does not interact with the intracellular domain of Notch. Its C-terminal region includes a C3HC4-type RING-HC finger, and a previously unidentified C-terminal domain.
Links
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Statistics
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PSSM-Id: 438371
Aligned: 7 rows
Threshold Bit Score: 99.8002
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #            # #  #  #          #  #            
Q8N9I9       161 ESTCPICLGEIqnAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQP 214 human
NP_956822    104 STVCSICMGEMveKTTLDKCGHAFCRSCLEQAFQVKKACPVCRLVYGQLIGNQP 157 zebrafish
NP_001106359  33 EEMCPICLSGFknKKTLDKCKHSFCEDCISRALQVKKACPMCGCLYGQLTGNQP 86  African clawed frog
KFO76637     147 ERQCPICLGEIqkMKTLEKCRHSFCEDCITRALQVKTACPMCGRFYGQLVGNQP 200 common cuckoo
XP_005986230 109 QDNCPICLGDIeaKKTLEKCGHSFCEDCLNQALKIKSTCPLCKEFYGKLIGNQP 162 coelacanth
XP_013409531 526 DETCPICMDSFqnKTTLDRCKHSFCKDCLDRSLQLKNKCPICGDILGEQTGDQP 579 Lingula anatina
XP_007890397 262 DKTCPVCLDEIneRETLKKCKHSFCRECIKAAFRVKSACPICGEVYGELMGNQP 315 elephant shark

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