Conserved Protein Domain Family
RING-CH-C4HC3_NFXL1
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cd16697: RING-CH-C4HC3_NFXL1 
RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins
NFXL1, also known as NF-X1-type zinc finger protein NFXL1, or ovarian zinc finger protein (OZFP), is encoded by the novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. It is a putative zinc finger protein with a C4HC3-type RING-CH finger and a Cys-rich region that harbors several NFX1-type zinc fingers.
Links
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Statistics
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PSSM-Id: 438358
Aligned: 22 rows
Threshold Bit Score: 69.6825
Created: 15-May-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of human FANCL with bound Zn2+ ions through its RING-CH finger
  • Comment:RING-CH finger (C4HC3-type)
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
  • Comment:The RING fingers found in NFXL1 and its homologs have an unusual arrangement of zinc-coordinating residues: The conserved helix complete with tryptophan at the C-terminal end is present but the cysteines and histidines are arranged in the sequence as C4HC3-type, rather than the typical C3H2C3-type in RING-H2 finger.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #            #   #    #  #                                       #  # 
Q6ZNB6       158 MTCLICIASVKRnQAVWSC-SGCFCIFHMpCIQKWAKDSqflvssvtd-----------ddfgkkdcpWPCPKCR 220  human
NP_001071880 128 ITCLVCISSVKRhEQIWSC-EKCFAIFHLpCIKQWVLEGvaqttllsa-----------ehfpkrdipWYCPKCR 190  vase tunicate
ELT89307     127 NVCLVCIETIKKnEAIWSC-CGCYSMFHInCIQKWVREGsfqranfe-------------daenkplpWCCPKCR 187  Capitella teleta
Q9FFK8        85 VSCLICLERIKRtDPTWSCtSSCFAVFHLfCIQSWARQCldlqaaravtr-------pssnptepeavWNCPKCR 152  thale cress
KIY94746      88 SMCLICLGSIKPsEAIWHCgGSCFAVFHLpCMQDWARNQidsaslrahna-------ngsapardeleFGCPKCR 155  Monoraphidium negle...
KDD73946     524 EACLVCLEPILAtEQVWQCtASCFVLAHFaCARAWAAQQrgkgdqep-------------skalaqggWTCPKCR 585  Helicosporidium sp....
XP_013092421 149 SACLVCIETIKKeEAIWNC-YGCFCMFHItCIQKWVREGvyqkqyssgdf--------iqeksstpisWHCPKCR 214  Biomphalaria glabrata
XP_019854902 132 SACLICLSSIRRvQPVWSC-LQCFCLFHLqCIQHWIKDGtqshallsa-----------hlfpdqerqWACPKCR 194  Amphimedon queensla...
XP_002987702  88 STCLICLEKIRKiDPIWHCkQGCFAVLHLvCIQSWARQVlstsenssagr--------nsssrtsparWHCPKCR 154  Selaginella moellen...
XP_024402753 121 TSCLICLERVRAtDPVWDCkAGCHVIFHLiCIQSWARQAlgaaairslgqlsgqhfpaaqaeaedkacWHCPKCR 195  Physcomitrium patens

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