Conserved Protein Domain Family
RING-H2_Vps8
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cd16687: RING-H2_Vps8 
RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
Vps8 is the Rab-specific subunit of the endosomal tethering complex CORVET (class C core vacuole/endosome transport) that also includes Vps3 and a Class C Vps core complex composed of Vps11, Vps16, Vps18, and Vps33. CORVET operates at endosomes, controls traffic into late endosomes, and interacts with the Rab5/Vps21-GTP form. The CORVET-specific Vps3 and Vps8 subunits belong to the class D Vps. They form a subcomplex that interact with Rab5/Vps21, and is critical for localization and function of the CORVET tethering complex on endosomes. Vps8 contains an N-terminal WD40 repeat and a C-terminal C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438348
Aligned: 15 rows
Threshold Bit Score: 58.6133
Created: 31-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #                                  # #  #  #                               
Q8N3P4       1256 DYCSICLQQYkrrq----------------emaDEIIVFSCGHLYHSFCLQNkectve---------------------- 1297 human
CAK10810       88 DHCNICLQQYkrrq----------------eseEEIVIFSCGHLYHCQCLQRketgvl---------------------- 129  zebrafish
XP_007905866 1226 EHCGICLQQYkrrq----------------egtEEVIVFSCGHIYHSQCLHNkncgvq---------------------- 1267 elephant shark
XP_006819234 1178 DNCHVCSKPHtdq------------------dqQSVCIFSCGHAYHTLCLLSvgsctm---------------------- 1217 Saccoglossus ...
ELU03031     1188 RSCNLCNKHIigggdevgcvvgfrsvmmvlifsHCTDCIRCGHGYHLTCLRSvgsral---------------------- 1245 Capitella teleta
XP_013387109 1242 GGCNLCAKLFvni-----------------tdnGAVIVFRCGHSYHAECLKSrgsfyk---------------------- 1282 Lingula anatina
XP_013089193 1250 NSCNVCNQTFnds-----------------sptETIIVFRCGHTYHTPCLRAvgsihv---------------------- 1290 Biomphalaria ...
XP_029850612 1254 ASCCACNKSFatg------------------elDDVVMFRCCHCYHRTCLEAsrsayvd--------------------- 1294 
P93043        886 TRCCMCFDPVsi-------------------rgDTVVVFFCCHAYHETCLMDaafsnnnhkttkgssgyeysydngvdee 946  thale cress
XP_024396786  875 GRCCICFDPVal-------------------qnVAVVAFFCTHAYHETCLNDtsgilpsdeseglrrsgsn--------- 926  Physcomitrium...

Feature 1                              #  # 
Q8N3P4       1298 -------------fegqtrWTCYKCS 1310 human
CAK10810      130 -------------serqypWSCYKCT 142  zebrafish
XP_007905866 1268 -------------tdgqtrWLCYKCN 1280 elephant shark
XP_006819234 1218 -------------idgqqhWFCYQCN 1230 Saccoglossus kowalevskii
ELU03031     1246 -------------mdgeevWLCYLCN 1258 Capitella teleta
XP_013387109 1283 -------------tigqeqWTCYLCS 1295 Lingula anatina
XP_013089193 1291 -------------legeevWVCYQCS 1303 Biomphalaria glabrata
XP_029850612 1295 -------------aggqvqWYCFRCF 1307 
P93043        947 eedeeededgdgdrpgrsrLRCILCT 972  thale cress
XP_024396786  927 -mndsaygleynsspdpapMRCILCT 951  Physcomitrium patens

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