2ECY


Conserved Protein Domain Family
RING-HC_TRAF3
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cd16640: RING-HC_TRAF3 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
TRAF3, also known as CAP-1, CD40 receptor-associated factor 1 (CRAF1), CD40-binding protein (CD40BP), or LMP1-associated protein 1 (LAP1), is a member of the TRAF protein family, which mainly functions in the immune system, where it mediates signaling through tumor necrosis factor receptors (TNFRs) and interleukin-1/Toll-like receptors (IL-1/TLRs). It also plays a unique cell type-specific and critical role in the restraint of B-cell homeostatic survival, a role with important implications for both B-cell differentiation and the pathogenesis of B-cell malignancies. TRAF3 differentially regulates differentiation of specific T cell subsets. It is required for iNKT cell development, restrains Treg cell development in the thymus, and plays an essential role in the homeostasis of central memory CD8+ T cells. TRAF3 contains an N-terminal domain with a typical C3HC4-type RING-HC finger and several zinc fingers, and a C-terminal TRAF domain that comprises a coiled coil domain, and a conserved TRAF-C domain.
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Statistics
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PSSM-Id: 438302
Aligned: 8 rows
Threshold Bit Score: 66.457
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C [CD]Click to see conserved feature residue pattern help
Evidence:
  • Structure:2ECY; Homo sapiens TRAF3 binds two Zn2+ ions through its RING-HC finger.
  • Comment:some members have a C3HC3D-type modified RING-HC finger
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #  #  #           #  # 
2ECY_A        16 YKCEKCHLVLCSPKQTECGHRFCESCMAALLssssPKCTACQ 57  human
XP_002938036  54 YKCEKCRLVLCNPRQTECGHRFCETCMNAILsstsPQCMACE 95  western clawed frog
XP_005987056  50 YKCEKCHHVLCNPRQTECGHRLCETCINAVLssirPQCPACE 91  coelacanth
XP_007886498  55 YKCEYCRHALCNPKQTECGHRFCESCLSNVFrnqnPVCPVDN 96  elephant shark
Q13114        51 YKCEKCHLVLCSPKQTECGHRFCESCMAALLssssPKCTACQ 92  human
NP_001003513  54 YCCETCRLVLCNPRQTECGHRFCESCINELLskpnPVCPADL 95  zebrafish
XP_018087811  46 YKCEKCRLVLCNPRQTECGHRFCETCMNAVLsssnSQCMACE 87  African clawed frog
RMB98707      50 YKCEKCHLILCNPKQTECGHRFCETCMNALLrsssPKCTACQ 91  Hirundo rustica rustica

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