5DIN,5H7R


Conserved Protein Domain Family
mRING-HC-C3HC3D_LNX1-like
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cd16637: mRING-HC-C3HC3D_LNX1-like 
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Modified RING finger, HC subclass (C3HC3D-type), found in ligand of Numb protein LNX1, LNX2, and similar proteins
The ligand of Numb protein X (LNX) family, also known as PDZ and RING (PDZRN) family, includes LNX1-5, which can interact with Numb, a key regulator of neurogenesis and neuronal differentiation. LNX5 (also known as PDZK4 or PDZRN4L) shows high sequence homology to LNX3 and LNX4, but it lacks the RING domain. LNX1-4 proteins function as E3 ubiquitin ligases and have a unique domain architecture consisting of an N-terminal RING-HC finger for E3 ubiquitin ligase activity and either two or four PDZ domains necessary for substrate-binding. LNX1/LNX2-like proteins contain a modified C3HC3D-type RING-HC finger and four PDZ domains. This model corresponds to the RING finger.
Links
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Statistics
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PSSM-Id: 438299
Aligned: 8 rows
Threshold Bit Score: 67.8079
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C [DE]Click to see conserved feature residue pattern help
Evidence:
  • Structure:5DIN; Homo sapiens LNX2 binds two Zn2+ ions through its modified RING-HC finger.
  • Comment:modified RING-HC finger (C3HC3D-type)
  • Comment:consensus of the typical C3HC4-type RING-HC finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #  #  #           #  # 
5DIN_A        30 DLVCHICLQPLLqPLDTPCGHTFCYKCLRNFLqe-kdFCPLDR 71  human
5H7R_D        28 DLICHICLQALLdPLDTPCGHTYCTLCLTNFLve-kdFCPMDR 69  human
ELU09902      33 DLMCHICLQPLVdPVDTKCGHTLCSLCLHNYLki-qsMCPVDR 74  Capitella teleta
XP_013397282  58 DLICHICLQPLVnPMDTRCGHTFCSECIKHYLki-qkICPLDR 99  Lingula anatina
KDR08075      51 DLTCHICLQPFVtPLDIPCGHTFCGACLNNYLrv-qqLCPIDR 92  Zootermopsis nevadensis
XP_019848881  94 DFLCAMCHKPLIePVETVCGHTFCYKCLFGRIrt-spYCPVEN 135 Amphimedon queenslandica
XP_014146303  18 DLTCSICSDAYSePLDTKCGHTFCKDCLSTWMkr-kkCCPLDN 59  Sphaeroforma arctica JP610
NP_511080    101 RYECAICIDWLNePVLTSCGHRFCRSCLTAWMqknnqCCPMDN 143 fruit fly

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