Conserved Protein Domain Family
RING-HC_ZNF598
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cd16615: RING-HC_ZNF598 
RING finger, HC subclass, found in zinc finger protein 598 (ZNF598) and similar proteins
ZNF598 associates with eukaryotic initiation factor 4E (eIF4E) homologous protein from mammals (m4EHP) by binding to Grb10-interacting GYF protein 2 (GIGYF2). The m4EHP-GIGYF2 complex functions as a translational repressor and is essential for normal embryonic development of mammalian. ZNF598 harbors a C3HC4-type RING-HC finger at its N-terminus.
Links
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Statistics
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PSSM-Id: 438277
Aligned: 40 rows
Threshold Bit Score: 76.1136
Created: 22-Sep-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #   #  #            #  #         
Q86UK7         27 GSCVLCCGDlEATALGRCDHP-VCYRCSTKMRVLceQRYCAVCREELRQVVF 77   human
XP_005819375    4 DVCLVCCEPlEHIAIGACNHRaVCALCSVRMRQLvgDLNCILCKQQLEQVII 55   Guillardia theta CCMP2712
ETO60577      116 EYCILCADPiRFFAVGECNHHgICSKCSMRMRLImdDRNCPMCKQPLDRVVV 167  Phytophthora parasitica P1976
XP_002504523    3 DCCAICAEPlTHVAYGPCGHRdACVECVARLRFVmeDRRCVICQVPCERVFA 54   Micromonas sp. RCC299
XP_011402091    3 DLCIVCAEPlVYTAYGPCGHQdACSKCVLRLRTImkDSRCVLCQQPCHAVFV 54   Auxenochlorella protothecoides
NP_191783       3 DSCAVCADNlEWVAYGSCGHReVCSTCVVRLRFVldDPRCCICKTESPIVFV 54   thale cress
PNW69875      281 LTCVICCEEvGWLAVGPCGHThTCARCCLRLRLLyrDNKCPLCKQDNKEVVV 332 
XP_001455324    6 SECVLCVQEaEIIALGHCNHKtFCYQCMIKMRVIskIKACPICKQILDKIIL 57   Paramecium tetraurelia strain d4-2
XP_002779873   60 EECSLCMEKlIYVAVGHCGHHsICWLCALRLRWLlnDRSCPMCKEELDTLVL 111  Perkinsus marinus ATCC 50983
PSC70944      397 PHCLVCCSEmAEVGMGACNHKeVCGQCTLRLRLCygRHDCPLCKTELKEVII 448  Micractinium conductrix

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