Conserved Protein Domain Family
RING-HC_TRIM10_C-IV
?
cd16593: RING-HC_TRIM10_C-IV 
RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
TRIM10, also known as B30-RING finger protein (RFB30), RING finger protein 9 (RNF9), or hematopoietic RING finger 1 (HERF1), is a novel hematopoiesis-specific RING finger protein required for terminal differentiation of erythroid cells. TRIM10 belongs to the C-IV subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Links
?
Statistics
?
PSSM-Id: 438255
Aligned: 6 rows
Threshold Bit Score: 114.62
Created: 21-Apr-2016
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #           # #  #  #                 #  #         
Q9UDY6         9 SLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGpdleeSPTCPLCKEPFRPGSF 69  human
EMP25600       9 DIQEEAICSICLGYLTEPVTIACGHNFCRACLTWYSEEKGmg--tPLTCPQCRAQFQKGEF 67  green sea turtle
Q7YR32         9 SLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGpdleeSPTCPLCKEPFRPGSF 69  chimpanzee
Q5E9G4         9 SLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSpdpeePPTCPLCKEPFRPGNF 69  cattle
XP_014428673  45 DIHDDAMCSMCLGYLTEPVTLACGHNFCRACLTQHREQRGtg--tPPTCPQCRAPFWHGEF 103 Chinese soft-shelled turtle
NP_439893      9 SLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGpdleeSPTCPLCKEPFRPGSF 69  human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap