Conserved Protein Domain Family
RING-HC_TRIM45_C-VII
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cd16588: RING-HC_TRIM45_C-VII 
RING finger, HC subclass, found in tripartite motif-containing protein 45 (TRIM45) and similar proteins
TRIM45, also known as RING finger protein 99 (RNF99), is a novel receptor for activated C-kinase (RACK1)-interacting protein that suppresses transcriptional activities of Elk-1 and AP-1 and downregulates mitogen-activated protein kinase (MAPK) signal transduction through inhibiting RACK1/PKC (protein kinase C) complex formation. It also negatively regulates tumor necrosis factor alpha (TNFalpha)-induced nuclear factor-kappaB (NF-kappa B)-mediated transcription and suppresses cell proliferation. TRIM45 belongs to the C-VII subclass of the TRIM (tripartite motif) family that is defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a filamin-type immunoglobulin (IG-FLMN) domain and NHL repeats positioned C-terminal to the RBCC domain.
Links
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Statistics
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PSSM-Id: 438250
Aligned: 6 rows
Threshold Bit Score: 82.9554
Created: 21-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #  #  #                                         #  #   
Q9H8W5         27 THCPLCLGLFkaPRLLPCLHTVCTTCLEQLEPFsvvdirggdsdtssegsifqelkprslqsqigILCPVCDAQ 100  human
AAH82821       14 TQCPQCQQPFcqPRILPCLHTLCGGCLAKLEPFsalgkgh------------------sagthwsVLCPVCDSE 69   western clawed frog
XP_005993667   33 THCPACGCLYlePRILPCLHTLCSSCIRQLEPVsvpglrvgdsdsgs-----egswareqpcpvsLLCPVCDSE 101  coelacanth
KQK79290        5 PRCPVCDEPWvsPRLLPCLHSLCSPCLRRLGTLaepgr----------------------aasrsVLCPVCDAE 56   blue-fronted amazon
KOC67134     1080 FRCPRCGKRMqePRLLPCLHPICSPCVSELMSRsfcnsvknvrtq--------sfqseseksnyyELCPLCDFQ 1145 Habropoda laboriosa
TRY96161       40 AVCAVCNRLYrePKILPCLHTFCSDCIRQLEPFsvcrldgdr---------------gspedgsaILCPECDSE 98   Danionella translucida

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